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	Provedor de dados BABT (2) Autor Muramoto,Emiko (2) Akanji,Akinkunmi Ganiyu (1) Araújo,Elaine Bortoleti de (1) Araújo,Elaine Bortoletti de (1) Caldeira Filho,José de Souza (1) Colturato,Maria Tereza (1) Couto,Renata Martinussi (1) Mais... Palavra-chave Adenocarcinomas (1) Anti-CD20 (1) Monoclonal antibody (1) Protein radioiodination (1) Radioimmunotherapy (1) Radioioactivity (1) Radiopharmaceuticals (1) VIP (1) VIP10-28 (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2005 (2) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Radiolabeling and biodistribution of monoclonal antibody (MAb) anti-CD20 with iodine-131 BABT Akanji,Akinkunmi Ganiyu; Muramoto,Emiko; Caldeira Filho,José de Souza; Couto,Renata Martinussi; Araújo,Elaine Bortoletti de. Radioactive isotopes of iodine, mainly iodine-131 have been broadly used in many monoclonal antibody radioiodination settings, employing different methods. In this study, using a Chloramine-T procedure, the influence of incubation time, CT mass, and Ab/activity ratio on the radiochemical yield of the anti-CD20 antibody labeled with iodine-131 was observed. Radiochemical yield was > 97 %, employing different Chloramine-T masses, independently of incubation time. Radiochemical purity was above 99 % after purification of the labeled compound. The relationship between Ab mass and radioactivity was tested and no difference was observed when 90.6 MBq (2.45mCi) of activity was incorporated in the Ab-mass range studied. Biodistribution study in normal Swiss... Tipo: Info:eu-repo/semantics/article Palavras-chave: Monoclonal antibody; Radioioactivity; Anti-CD20; Radioimmunotherapy. Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132005000700010 Comparative biodistribution profile of [131I]VIP and [131I]VIP10-28 BABT Colturato,Maria Tereza; Muramoto,Emiko; Araújo,Elaine Bortoleti de. Various tumor cells express significantly higher amounts of VIP receptors (VIPR) that provided the basis for the clinical use of radiolabeled VIP for the in vivo localization of tumors. This work studied the labeling of VIP and VIP10-28 with iodine-131 to compare the biological distribution of the labeled compounds in Nuce mice and the affinity for tumor cells. Both VIP and VIP10-28 peptides contain two tyrosine residues, in positions 10 and 22, that are theoretically equally susceptible to radioiodination employing oxidative electrophilic substitution using oxidizing agents like Chloramine T. Radiochemical purity of the reaction mixture was determined by electrophoresis and HPLC. The VIP peptide and the fragment were labeled with radioiodine with good... Tipo: Info:eu-repo/semantics/article Palavras-chave: Radiopharmaceuticals; Protein radioiodination; VIP; VIP10-28; Adenocarcinomas. Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132005000700012 Registros recuperados: 2 Primeira ... 1 ... Última

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