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| SUEUR-MALUF,LUCIANA LE; VIANA,MILENA B.; NAGAOKA,MÁRCIA R.; AMORIM,ANA LAURA B.; CARDOSO,AMANDA N.; RODRIGUES,BRUNA C.; MENDES,NATÁLIA F.; BITTENCOURT,JACKSON C.; CÉSPEDES,ISABEL C.. |
| Hepatic encephalopathy (HE) encompasses a variety of neuropsychiatric symptoms, including anxiety and psychomotor dysfunction. Although HE is a frequent complication of liver cirrhosis, the neurobiological substrates responsible for its clinical manifestations are largely unclear. In the present study, male Wistar rats were bile duct-ligated (BDL), a procedure which induces liver cirrhosis, and on the 21st day after surgery tested in the elevated plus-maze (EPM) and in an open field for anxiety and locomotor activity measurements. Analysis of Fos protein immunoreactivity (Fos-ir) was used to better understand the neurobiological alterations present in BDL animals. Plasma levels of ammonia were quantified and histopathological analysis of the livers was... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Anxiety; Bile-duct ligation; Fos-immunoreactivity; Hepatic encephalopathy; Locomotor activity. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652015000100331 |
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