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| LIPINSKI,LEANDRO C.; KMETIUK,LOUISE B.; MATHIAS,PAULO C.F.; MALTA,ANANDA; FAVERO,GIOVANI M.; RIBEIRO,TATIANE A.; TOLEDO,ALCEU; NETTO,MARIO R. MONTEMOR; RODRIGUES,MARCOS R.S.. |
| ABSTRACT Introduction/Aim: The gut has shown to have a pivotal role on the pathophysiology of metabolic disease. Food stimulation of distal intestinal segments promotes enterohormones secretion influencing insulin metabolism. In diabetic rats, oral insulin has potential to change intestinal epithelium behavior. This macromolecule promotes positive effects on laboratorial metabolic parameters and decreases diabetic intestinal hypertrophy. This study aims to test if oral insulin can influence metabolic parameters and intestinal weight in obese non-diabetic rats. Methods: Twelve weeks old Wistar rats were divided in 3 groups: control (CTRL) standard chow group; high fat diet low carbohydrates group (HFD) and HFD plus daily oral 20U insulin gavage (HFD+INS).... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Oral insulin; Intestine; Diabetes; Obesity; Metabolism; Pancreatic beta-cell. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000401699 |
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