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| FIGUEIREDO,CLAUDIA P.; FERREIRA,NATALIA C.; PASSOS,GISELLE F.; COSTA,ROBSON DA; NEVES,FERNANDA S.; MACHADO,CLARICE S.C.; MASCARELLO,ALESSANDRA; CHIARADIA-DELATORRE,LOUISE D.; NEUENFELDT,PATRÍCIA D.; NUNES,RICARDO J.; CORDEIRO,YRAIMA. |
| An altered form of the cellular prion protein, the PrPScor PrPRes, is implicated in the occurrence of the still untreatable transmissible spongiform encephalopathies. We have previously synthesized and characterized aromatic compounds that inhibit protease-resistant prion protein (PrPRes) accumulation in scrapie-infected cells. These compounds belong to different chemical classes, including acylhydrazones, chalcones and oxadiazoles. Some of the active compounds were non-toxic to neuroblastoma cells in culture and seem to possess drugable properties, since they are in agreement with the Lipinski´s rule of 5 and present desirable pharmacokinetic profiles as predicted in silico. Before the evaluation of the in vivo efficacy of the aromatic compounds in... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Prion; Acute toxicity; Organic compound; Drug safety; Scrapie; Pharmacokinetics. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652015000301421 |
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