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| Scorza,Fulvio A.; Arida,Ricardo M.; Naffah-Mazzacoratti,Maria da Graça; Scerni,Débora A.; Calderazzo,Lineu; Cavalheiro,Esper A.. |
| The systemic administration of a potent muscarinic agonist pilocarpine in rats promotes sequential behavioral and electrographic changes that can be divided into 3 distinct periods: (a) an acute period that built up progressively into a limbic status epilepticus and that lasts 24 h, (b) a silent period with a progressive normalization of EEG and behavior which varies from 4 to 44 days, and (c) a chronic period with spontaneous recurrent seizures (SRSs). The main features of the SRSs observed during the long-term period resemble those of human complex partial seizures and recurs 2-3 times per week per animal. Therefore, the pilocarpine model of epilepsy is a valuable tool not only to study the pathogenesis of temporal lobe epilepsy in human condition, but... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Hippocampus; Pilocarpine; Temporal lobe epilepsy; Rat. |
| Ano: 2009 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652009000300003 |
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