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Safety aspects of protease inhibitors for chronic hepatitis C: adverse events and drug-to-drug interactions BJID
Teixeira,Rosângela; Nascimento,Yone de Almeida; Crespo,Déborah.
The standard of care therapy of chronic hepatitis C with the combination of pegylated interferon and ribavirin for 24 or 48 weeks was a remarkable accomplishment of the past decade. However, sustained virological responses rates of about 80% (genotypes 2-3) and 50% (geno 3 type 1) were not satisfactory especially for patients infected with genotype 1. Important advances in the biology of HCV have made possible the development of the direct-acting antiviral agents boceprevir and telaprevir with substantial increase in the rates of sustained virological response with shorter duration of therapy for a large number of patients. However, the complexity of triple therapy is higher and several new side effects are expected suggesting greater expertise in the...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Hepatitis C; Protease inhibitors; Adverse events; Drug interactions.
Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000200013
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Drug-related problems observed in a pharmaceutical care service, Belo Horizonte, Brazil BJPS
Nascimento,Yone de Almeida; Carvalho,Wânia da Silva; Acurcio,Francisco de Assis.
This present observational, longitudinal, and non-concurrent study was developed with the purposes of evaluate the profile of patients attended by a pharmacotherapeutic follow-up service and describe the Drug-Related Problems (DRPs) found over there; determine the proportion of DRPs between the health problems presented by the studied population, classifying them and identifying the situations related with their appearance. The study was developed at the School Pharmacy of Newton Paiva University Center, Belo Horizonte, MG, during the period from 2001 November up to 2003 November. Ninety seven patients have been evaluated, the majority of female sex (66.0%), with up to 8 years of scholarship (45.4%), mean age of 56.7 ± 13.0 years; mean of 4 ± 2 diagnosed...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Pharmaceutical care; Pharmacotherapeutic follow-up; Drug Related Problem (DRP).
Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502009000200018
Registros recuperados: 2
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