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| Natalia N. Kudryavtseva. |
| Of all the models used by behavioral neuroscience the biosocial models are gaining in popularity among the scientists who study the consequences of chronic social conflicts and social stress in animals. One of such models, the Standardized Model for Repeated Social Defeat Stress (SMRSDS) (Golden et al., 2011) has been widely applied to produce important results on the molecular mechanisms of the social defeat stress (Berton et al., 2006). SMRSDS is a modified version of the Sensory Contact Model (SCM) (Kudryavtseva, 1991), which has been used by different laboratories in its original or modified forms for elucidating implications of chronic social conflicts. The basic design and justification of the SCM different stages are described in detail in the... |
| Tipo: Manuscript |
Palavras-chave: Neuroscience. |
| Ano: 2011 |
URL: http://precedings.nature.com/documents/6411/version/1 |
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| Ul’yana A. Boyarskikh; Natalya P. Bondar; Maxim L. Filipenko; Natalia N. Kudryavtseva. |
| Background: 
There is ample experimental evidence supporting the hypothesis that the brain serotonergic system is involved in the control of chronic social defeat stress (CSDS), depression and anxiety. The study aimed to analyze mRNA levels of the serotonergic genes in the raphe nuclei of the midbrain that may be associated with chronic social defeats consistently shown by male mice in special experimental settings. 

Methodology/Principal Findings: 
The serotonergic genes were the Tph2, Sert, Maoa and Htr1a. The Bdnf, Creb, Cphn, Gapdh, Hprt, B2M, 18S and Actb genes were also studied. The experimental groups were composed of male mice with experience of defeats in 21 daily encounters and... |
| Tipo: Manuscript |
Palavras-chave: Neuroscience. |
| Ano: 2011 |
URL: http://precedings.nature.com/documents/6543/version/1 |
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| Natalia N. Kudryavtseva; Natalia P. Bondar; Ul'yana A. Boyarskikh; Maxim L. Filipenko. |
| The study aimed to analyze the mRNA levels of Snca and Bdnf genes in the ventral tegmental area (VTA) and raphe nuclei of the midbrain in male mice that had each won or defeated 20 encounters in daily agonistic interactions. Groups of animals that had the same winning and losing track record followed by a no-fight period for 14 days were also studied. Snca mRNA levels were increased in the raphe nuclei in the losers and in the VTA of the winners. After fighting deprivation Snca mRNA levels were decreased to the control level in both groups. Snca mRNA levels were similar to the control level in the VTA of the losers and in the raphe nuclei of the winners. However Snca gene expression was increased in these areas after no-fight period in the winners and... |
| Tipo: Manuscript |
Palavras-chave: Molecular Cell Biology; Neuroscience. |
| Ano: 2010 |
URL: http://precedings.nature.com/documents/4327/version/1 |
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| Natalia N. Kudryavtseva; Natalia P. Bondar; Irina L. Kovalenko; Damira F. Avgustinovich. |
| Hedonic reactions to various rewards play a key role in various forms of motivated behavior. The influence of repeated experience of social victories or defeats in daily agonistic interactions between male mice on voluntary consumption of vanillin sucrose solution used as hedonic reinforcer was studied. Intake of vanillin sucrose solution was shown to decrease in the winners and losers exposed to social confrontations as compared with the controls. Three days of deprivation failed to restore the intake of vanillin sucrose solution to the control level in the losers and did so in the winners. The results obtained imply that similar reaction of animals to a hedonic non-drug reinforcer may have different motivational origin depending on positive or negative... |
| Tipo: Manuscript |
Palavras-chave: Neuroscience. |
| Ano: 2007 |
URL: http://precedings.nature.com/documents/988/version/1 |
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| Natalia P. Bondar; Irina L. Kovalenko; Damira F. Avgustinovich; Dmitry A. Smagin; Natalia N. Kudryavtseva. |
| One of the core symptoms of major depression in human is anhedonia. For that reason, one of the main requirements towards experimental depression models is that they be able to demonstrate anhedonia in animals, that have been exposed to stressful events, and other behavioral changes attributable to a depression-like state. However, the results presented in the literature are contradictory: sweet solution intake, which is considered as a parameter of hedonic/anhedonic behavior in animals, responds quite differently to stressful situations in that it is either unaffected or increased or decreased. Different experimental designs used for the study of anhedonia in male mice exposed to chronic social defeat stress were tried to understand the reasons for so... |
| Tipo: Manuscript |
Palavras-chave: Neuroscience. |
| Ano: 2008 |
URL: http://precedings.nature.com/documents/2682/version/1 |
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