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Nuclear calcium signaling: a cell within a cell BJMBR
Rodrigues,M.A.; Gomes,D.A.; Nathanson,M.H.; Leite,M.F..
Calcium (Ca2+) is a versatile second messenger that regulates a wide range of cellular functions. Although it is not established how a single second messenger coordinates diverse effects within a cell, there is increasing evidence that the spatial patterns of Ca2+ signals may determine their specificity. Ca2+ signaling patterns can vary in different regions of the cell and Ca2+ signals in nuclear and cytoplasmic compartments have been reported to occur independently. No general paradigm has been established yet to explain whether, how, or when Ca2+ signals are initiated within the nucleus or their function. Here we highlight that receptor tyrosine kinases rapidly translocate to the nucleus. Ca2+ signals that are induced by growth factors result from...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Calcium; Proliferation; Receptor tyrosine kinases; Nucleus.
Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000100004
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