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	Provedor de dados 74 (2) Autor Nepomuceno,Júlio César (2) Costa,Wender Ferreira (1) Lopes,Jeyson Césary (1) Machado,Nayane Moreira (1) Oliveira,Alaide Braga de (1) Saturnino,Rosiane Soares (1) Mais... Palavra-chave Drosophila melanogaster (2) SMART (2) Cytochrome P450 (1) Doxorubicin (1) Lapachol (1) Mutagenicity (1) Pantoprazole (1) Proton pump inhibitors (1) Recombinogenicity (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2015 (1) 2010 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Genotoxicity of lapachol evaluated by wing spot test of Drosophila melanogaster 74 Costa,Wender Ferreira; Oliveira,Alaide Braga de; Nepomuceno,Júlio César. This study investigated the genotoxicity of Lapachol (LAP) evaluated by wing spot test of Drosophila melanogaster in the descendants from standard (ST) and high bioactivation (HB) crosses. This assay detects the loss of heterozygosity of marker genes expressed phenotypically on the fly's wings. Drosophila has extensive genetic homology to mammals, which makes it a suitable model organism for genotoxic investigations. Three-day-old larvae from ST crosses (females flr³/TM3, Bd s x males mwh/mwh), with basal levels of the cytochrome P450 and larvae of high metabolic bioactivity capacity (HB cross) (females ORR; flr³/TM3, Bd s x males mwh/mwh), were used. The results showed that LAP is a promutagen, exhibiting genotoxic activity in larvae from the HB cross. In... Tipo: Info:eu-repo/semantics/article Palavras-chave: Drosophila melanogaster; SMART; Lapachol; Doxorubicin; Cytochrome P450. Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572010000300029 Recombinogenic activity of Pantoprazole® in somatic cells of Drosophila melanogaster 74 Lopes,Jeyson Césary; Machado,Nayane Moreira; Saturnino,Rosiane Soares; Nepomuceno,Júlio César. Pantoprazole® is one of the leading proton pump inhibitors (PPIs) used in the treatment of a variety of diseases related to the upper gastrointestinal tract. However, studies have shown an increased risk of developing gastric cancer, intestinal metaplasia and hyperplasia of endocrine cells with prolonged use. In the present study, the somatic mutation and recombination test (SMART) was employed to determine the mutagenic effects of Pantoprazole on Drosophila melanogaster. Repeated treatments with Pantoprazole were performed on 72-hour larvae of the standard (ST) and high bioactivation (HB) crosses at concentrations of 2.5, 5.0, and 10.0 μM. In addition, doxorubicin (DXR) was administered at 0.4 mM, as a positive control. When administered to ST... Tipo: Info:eu-repo/semantics/article Palavras-chave: Drosophila melanogaster; Mutagenicity; Proton pump inhibitors; Pantoprazole; Recombinogenicity; SMART. Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572015000100101 Registros recuperados: 2 Primeira ... 1 ... Última

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