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Increased risk of venous thrombosis by AB alleles of the ABO blood group and Factor V Leiden in a Brazilian population Genet. Mol. Biol.
Lima,Magaly B.P.L.V.; Oliveira-Filho,Aldemir Branco de; Campos,Júlia F.; Melo,Fárida C.B.C.; Neves,Washington Batista das; Melo,Raul Antônio Morais; Lemos,José Alexandre Rodrigues.
Most cases of a predisposition to venous thrombosis are caused by resistance to activated protein C, associated in 95% of cases with the Factor V Leiden allele (FVL or R506Q). Several recent studies report a further increased risk of thrombosis by an association between the AB alleles of the ABO blood group and Factor V Leiden. The present study investigated this association with deep vein thrombosis (DVT) in individuals treated at the Hemocentro de Pernambuco in northeastern Brazil. A case-control comparison showed a significant risk of thrombosis in the presence of Factor V Leiden (OR = 10.1), which was approximately doubled when the AB alleles of the ABO blood group were present as well (OR = 22.3). These results confirm that the increased risk of deep...
Tipo: Info:eu-repo/semantics/article Palavras-chave: ABO blood group; Factor V Leiden; Venous thrombosis.
Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572009000200010
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