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An open label, multicenter, non-comparative study of the efficacy and safety of oral gatifloxacin in the treatment of community-acquired pneumonia: a Brazilian study in five centers BJID
Nicodemo,Antonio Carlos.
We made an open label, multicenter, non-comparative study to assess the efficacy and safety of oral gatifloxacin, 400mg PO given once-daily during 7 to 14 days for the treatment of adult outpatients with community-acquired pneumonia at five Brazilian medical facilities. Among the 86 subjects available for clinical evaluation, 84 (98%) were cured. The bacteriological eradication and presumed eradication rate was 98% (52/53) among the 44 (51%) patients who were bacteriologically evaluated. Drug-related adverse events were reported by 27% of the patients, diarrhea being the most frequent, occurring in 12% of patients. Adverse events were considered mild (89%) or moderate (11%). We conclude that a 7-14 day course of gatifloxacin, 400mg PO given once daily is...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Gatifloxacin; Community-acquired pneumonia; Brazil.
Ano: 2003 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000100007
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Rothia aeria endocarditis in a patient with a bicuspid aortic valve: case report BJID
Nicodemo,Antonio Carlos; Gonçalves,Luiz Guilherme; Odongo,Fatuma Catherine Atieno; Martino,Marines Dalla Valle; Sampaio,Jorge Luiz Mello.
Rothia aeria is an uncommon pathogen mainly associated with endocarditis in case reports. In previous reports, endocarditis by R. aeria was complicated by central nervous system embolization. In the case we report herein, endocarditis by R. aeria was diagnosed after acute self-limited diarrhea. In addition to the common translocation of R. aeria from the oral cavity, we hypothesize the possibility of intestinal translocation. Matrix-assisted laser desorption ionization-time of flight mass spectrometry and genetic sequencing are important tools that can contribute to early and more accurate etiologic diagnosis of severe infections caused by Gram-positive rods.
Tipo: Info:eu-repo/semantics/report Palavras-chave: Rothia aeria; Endocarditis; Intestinal translocation; Molecular diagnosis.
Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000500561
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Strong correlation by ultrasonography of hepatomegaly and the presence of co-infection in HIV/HCV cirrhotic patients BJID
Vezozzo,Denise Cerqueira Paranaguá; Mendes-Correa,Maria Cassia; Cunha-Silva,Marlone; Alvarado-Mora,Mónica Viviana; França,João Ítalo Dias; Sebba,José Luiz; Nicodemo,Antonio Carlos; Oliveira,Claudia P.M.S.; Carrilho,Flair José.
OBJECTIVES: Progression of hepatic fibrosis is accelerated in patients co-infected with human immunodeficiency virus and hepatitis C virus compared to hepatitis C virus mono-infected patients. This study aimed to compare ultrasound features and selected clinical and biochemical variables between patients with human immunodeficiency virus/hepatitis C virus co-infection (n = 16) versus hepatitis C virus mono-infection (n = 16). METHODS: Each patient underwent abdominal ultrasound, and a specific evaluation was performed in order to detect findings consistent with chronic liver disease. Characterization of spleen size, liver structural pattern, diameter of the portal, spleen, and mesenteric veins was based on classical ultrasound parameters. Propensity score...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Ultrasonography; HIV/HCV co-infection; Hepatomegaly; Liver size; Cirrhosis.
Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000200006
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Antimicrobial susceptibility of Brazilian Clostridium difficile strains determined by agar dilution and disk diffusion BJID
Fraga,Edmir Geraldo; Nicodemo,Antonio Carlos; Sampaio,Jorge Luiz Mello.
Abstract Clostridium difficile is a leading cause of diarrhea in hospitalized patients worldwide. While metronidazole and vancomycin are the most prescribed antibiotics for the treatment of this infection, teicoplanin, tigecycline and nitazoxanide are alternatives drugs. Knowledge on the antibiotic susceptibility profiles is a basic step to differentiate recurrence from treatment failure due to antimicrobial resistance. Because C. difficile antimicrobial susceptibility is largely unknown in Brazil, we aimed to determine the profile of C. difficile strains cultivated from stool samples of inpatients with diarrhea and a positive toxin A/B test using both agar dilution and disk diffusion methods. All 50 strains tested were sensitive to metronidazole according...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Clostridium difficile; Disk diffusion; Agar dilution; Susceptibility testing.
Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000500476
Registros recuperados: 4
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