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| Coelho,Angélica Gomes; Lima Neto,José de Sousa; Moura,Arkellau Kenned Silva; Morais,Ilmara Cecilia Pinheiro da Silva; Cunha,Francisco Valmor Macedo; Melo-Neto,Bernardo; Medeiros,Maria das Graças Freire de; Vasconcelos,Eilika Andreia Feitosa; Arcanjo,Daniel Dias Rufino; Nunes,Lívio Cesar Cunha; Citó,Antônia Maria das Graças Lopes. |
| ABSTRACT Lippia origanoides is a honey shrub which has showed hypotensive potential assessed by in vivo studies. The aim of this work is the development of a pharmaceutical formulation composed by an optimized extract obtained from aerial parts of L. origanoides. The quantification of the naringenin marker in the dry extract and tablets developed was performed, as well as the assessment of the oral acute toxicity in rats. The hydroalcoholic extract of L. origanoides was spray-dried with the addition of colloidal silicon dioxide (Lo-HAE/CSD), and then applied in the preparation of eight different lots of tablets. The influence of the diluent (cellulose or babassu mesocarp), the presence of binder, and the percentage of lubricant, as well as organoleptic and... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Lippia origanoides/pharmaceutical formulation/toxicity/; Babassu mesocarp; Factorial planning; Tablets.. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000200619 |
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