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| Nunes,Melise Silveira; Garzon,Litiérri Razia; Rampelotto,Roberta Filipini; Tizotti,Maísa Kräulich; Martini,Rosiéli; Locatelli,Aline; Barbosa,Marcelo; Hörner,Manfredo; Hörner,Rosmari. |
| ABSTRACT The enhancement of anti-leukemia therapy and the treatment of infections caused by multidrug-resistant pathogens are major challenges in healthcare. Although a large arsenal of drugs is available, many of these become ineffective, and as a result, the discovery of new active substances occurs. Notably, triazenes (TZCs) have been consolidated as a promising class of compounds, characterized by significant biological activity, especially antiproliferative and antimicrobial properties. The aim of this study is the synthesis and characterization of a new triazenide complex of gold (I), as well as the in vitro assessment of its antiproliferative activity against the K562 cell line (Chronic Myeloid Leukemia), and antibacterial activity against bacterial... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Triazenes/synthesis/characterization/biological activity; TZC/Gold ion complexed; Chronic myeloid leukemia; Antibacterial activity. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000400617 |
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