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Interchromosomal distribution of gamma ray-induced chromatid aberrations in Chinese hamster ovary cells Genet. Mol. Biol.
Martínez-López,Wilner; Porro,Valentina; Folle,Gustavo A.; Mendez-Acuña,Leticia; Savage,John R.K.; Obe,Günter.
Interchromosomal distributions of breakpoints from chromatid-type aberrations induced by gamma rays in Chinese hamster ovary (CHO) cells were analyzed. In most chromosomes the distribution was as expected from chromosome lengths for simple breaks or the respective relative corrected length in case of exchanges. There were deviations from expectation in a few chromosomes for chromatid breaks, interchanges, intra-arm intrachanges and inter-arm intrachanges. Especially interesting are the results concerning chromosomes 2 and 8, which were more often involved in exchanges than expected. An "exchange phenotype" for these chromosomes is proposed and possible explanations for the nonrandom distribution of chromosome breakpoints are presented.
Tipo: Info:eu-repo/semantics/article
Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572000000400053
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A proposal of a standardised nomenclature for terminal minute sister chromatid exchanges Genet. Mol. Biol.
Drets,Máximo E.; Santiñaque,Federico F.; Obe,Günter.
We described spontaneous minute sister chromatid exchanges (SCE) in telomeric regions of human and Chinese hamster ovary (CHO) chromosomes more than 10 years ago. These structures, which we called t-SCE, were detected by means of highly precise quantitative microphotometrical scanning and computer graphic image analysis. Recently, several authors using the CO-FISH method also found small SCEs in telomeric regions and called them T-SCE. The use of different terms for designating the same phenomenon should be avoided. We propose ter SCE as a uniform nomenclature for minute telomeric SCEs.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Minute telomeric SCEs; Chromosome nomenclature.
Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572006000300007
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