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| Santos,L.H.; Feres,C.A.O.; Melo,F.H.; Coelho,M.M.; Nothenberg,M.S.; Oga,S.; Tagliati,C.A.. |
| We investigated the anti-inflammatory, antinociceptive and ulcerogenic activity of a zinc-diclofenac complex (5.5 or 11 mg/kg) in male Wistar rats (180-300 g, N = 6) and compared it to free diclofenac (5 or 10 mg/kg) and to the combination of diclofenac (5 or 10 mg/kg) and zinc acetate (1.68 or 3.5 mg/kg). The carrageenin-induced paw edema and the cotton pellet-induced granulomatous tissue formation models were used to assess the anti-inflammatory activity, and the Hargreaves model of thermal hyperalgesia was used to assess the antinociceptive activity. To investigate the effect of orally or intraperitoneally (ip) administered drugs on cold-induced gastric lesions, single doses were administered before exposing the animals to a freezer (-18ºC) for 45 min... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Diclofenac-zinc complex; Gastric lesions; Non-steroidal anti-inflammatory drugs; Ulcerogenesis; Antinociception. |
| Ano: 2004 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000800011 |
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