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	Provedor de dados BJMBR (3) Autor Cicogna,A.C. (3) Okoshi,M.P. (3) Fioretto,J.R. (2) Matsubara,B.B. (2) Matsubara,L.S. (2) Okoshi,K. (2) Aragon,F.F. (1) Bonatto,R.C. (1) Franco,M. (1) Padovani,C.R. (1) Tucci,P.J.F. (1) Mais... Palavra-chave Papillary muscle (2) Afterload (1) Coronary vascular remodeling (1) DP/dt (1) DT/dt (1) Echocardiogram (1) Isolated heart (1) Isometric contractions (1) Langendorff preparation (1) Myocardial function (1) Pressure overload hypertrophy (1) Reparative fib (1) Undernutrition (1) Ventricular function (1) Ventricular remodeling (1) Mais... Tipo do documento Info:eu-repo/semantics/article (3) Ano 2004 (1) 1997 (2) País Brazil (3) Idioma Inglês (3)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 3 Primeira ... 1 ... Última Food restriction induces in vivo ventricular dysfunction in spontaneously hypertensive rats without impairment of in vitro myocardial contractility BJMBR Okoshi,K.; Fioretto,J.R.; Okoshi,M.P.; Cicogna,A.C.; Aragon,F.F.; Matsubara,L.S.; Matsubara,B.B.. Cardiac structures, function, and myocardial contractility are affected by food restriction (FR). There are few experiments associating undernutrition with hypertension. The aim of the present study was to analyze the effects of FR on the cardiac response to hypertension in a genetic model of hypertension, the spontaneously hypertensive rat (SHR). Five-month-old SHR were fed a control or a calorie-restricted diet for 90 days. Global left ventricle (LV) systolic function was evaluated in vivo by transthoracic echocardiogram and myocardial contractility and diastolic function were assessed in vitro in an isovolumetrically beating isolated heart (Langendorff preparation). FR reduced LV systolic function (control (mean ± SD): 58.9 ± 8.2; FR: 50.8 ± 4.8%, N =... Tipo: Info:eu-repo/semantics/article Palavras-chave: Undernutrition; Isolated heart; Echocardiogram; Langendorff preparation; Ventricular remodeling. Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000400019 The rate of force generation by the myocardium is not influenced by afterload BJMBR Fioretto,J.R.; Okoshi,M.P.; Okoshi,K.; Cicogna,A.C.; Bonatto,R.C.; Padovani,C.R.; Tucci,P.J.F.. The influence of afterload on the rate of force generation by the myocardium was investigated using two types of preparations: the in situ dog heart (dP/dt) and isolated papillary muscle of rats (dT/dt). Thirteen anesthetized, mechanically ventilated and thoracotomized dogs were submitted to pharmacological autonomic blockade (3.0 mg/kg oxprenolol plus 0.5 mg/kg atropine). A reservoir connected to the left atrium permitted the control of left ventricular end-diastolic pressure (LVEDP). A mechanical constriction of the descending thoracic aorta allowed to increase the systolic pressure in two steps of 20 mmHg (conditions H1 and H2) above control values (condition C). After arterial pressure elevations (systolic pressure C: 119 ± 8.1; H1: 142 ± 7.9; H2 166 ±... Tipo: Info:eu-repo/semantics/article Palavras-chave: Ventricular function; Afterload; DP/dt; DT/dt; Papillary muscle; Isometric contractions. Ano: 1997 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997001200015 Myocyte necrosis is the basis for fibrosis in renovascular hypertensive rats BJMBR Okoshi,M.P.; Matsubara,L.S.; Franco,M.; Cicogna,A.C.; Matsubara,B.B.. The pathogenesis of fibrosis and the functional features of pressure overload myocardial hypertrophy are still controversial. The objectives of the present study were to evaluate the function and morphology of the hypertrophied myocardium in renovascular hypertensive (RHT) rats. Male Wistar rats were sacrificed at week 4 (RHT4) and 8 (RHT8) after unilateral renal ischemia (Goldblatt II hypertension model). Normotensive rats were used as controls. Myocardial function was analyzed in isolated papillary muscle preparations, morphological features were defined by light microscopy, and myocardial hydroxyproline concentration (HOP) was determined by spectrophotometry. Renal artery clipping resulted in elevated systolic arterial pressure (RHT4: 178 ± 19 mmHg and... Tipo: Info:eu-repo/semantics/article Palavras-chave: Coronary vascular remodeling; Myocardial function; Pressure overload hypertrophy; Papillary muscle; Reparative fib. Ano: 1997 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997000900013 Registros recuperados: 3 Primeira ... 1 ... Última

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