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| Namazu, L. B.; Calefi, A. S.; Gimenes, D.; Oliveira, R.; Cohn, D. W.; Lima, A. P. N.; Vitoretti, L. B.; Drewes, C. C.; Amaya, J. E. O.; Borsoi, A.; Reis-Silva, T. M.; Massoco, C. O.; Costa Pinto, F. A.. |
| Introduction: inflammatory bowel disease (IBD) in humans is a chronic disease of complex ethiology that manifests as Crohn’s disease (CD) or ulcerative colitis (UC). It involves an exacerbated immune reaction to the gut microbiota. The nervous system interacts with immunity in the gut in a bidirectional fashion. Inflammation is modulated by neural activity and may lead to emotional and psychological changes. Amitriptyline (AMT) is a commonly used antidepressant with known anti-inflammatory activities.Objective: It was hypothesized that antidepressants like amitriptyline could be considered as a prophilatic treatment and attenuation of development of IBD in mice.Material and Methods: C57BL/6 mices were housed in groups of five per cage with free access to... |
| Tipo: Info:eu-repo/semantics/article |
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| Ano: 2015 |
URL: http://www.revistamvez-crmvsp.com.br/index.php/recmvz/article/view/25721 |
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