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| Oliveira,Isabela S.; Cabral,Milena S.; Jesus,Larissa S.; Paraná,Raymundo; Atta,Ajax M.; Atta,Maria Luiza B. Sousa. |
| Hepatitis C virus (HCV) infects B-lymphocytes, provokes cellular dysfunction and causes lymphoproliferative diseases such as cryoglobulinemia and non-Hodgkin's B-cell lymphoma. In the present study, we investigated the serum levels of kappa and lambda free light chains (FLC) of immunoglobulins and the kappa/lambda FLC ratio in Brazilian patients with chronic HCV infection and cryoglobulinemia. We also analyzed the immunochemical composition of the cryoglobulins in these patients. Twenty-eight cryoglobulinemic HCV patients composed the target group, while 37 HCV patients without cryoglobulinemia were included as controls. The median levels of kappa and lambda FLC were higher in patients with cryoglobulinemia compared to controls (p = 0.001 and p = 0.003,... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Chronic hepatitis C; Cryoglobulin; Free light chain; B-cell polyclonal activation. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000600638 |
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