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| Oliveira,J.R.M.; Zatz,M.. |
| Genetic and environmental factors have been implicated in the development of Alzheimer's disease (AD), the most common form of dementia in the elderly. Mutations in 3 genes mapped on chromosomes 21, 14 and 1 are related to the rare early onset forms of AD while the <FONT FACE="Symbol">e</font>4 allele of the apolipoprotein E (APOE) gene (on chromosome 19) is the major susceptibility locus for the most common late onset AD (LOAD). Serotonin (5-hydroxytryptamine or 5-HT) is a key neurotransmitter implicated in the control of mood, sleep, appetite and a variety of traits and behaviors. Recently, a polymorphism in the transcriptional control region upstream of the 5-HT transporter (5-HTT) gene has been studied in several psychiatric diseases and... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Alzheimer's disease; Allelic association; Serotonin polymorphisms. |
| Ano: 1999 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000400014 |
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| Lima,S.G.; Albuquerque,M.F.P.M.; Oliveira,J.R.M.; Ayres,C.F.J.; Cunha,J.E.G.; Oliveira,D.F.; Lemos,R.R.; Souza,M.B.R.; Silva,O. Barbosa e. |
| Exaggerated blood pressure response (EBPR) during the exercise treadmill test (ETT) has been considered to be a risk factor for hypertension. The relationship of polymorphisms of the renin-angiotensin system gene with hypertension has not been established. Our objective was to evaluate whether EBPR during exercise is a clinical marker for hypertension. The study concerned a historical cohort of normotensive individuals. The exposed individuals were those who presented EBPR. At the end of the observation period (41.7 months = 3.5 years), the development of hypertension was analyzed within the two groups. Genetic polymorphisms and blood pressure behavior were assessed as independent variables, together with the classical risk factors for hypertension. The... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Hypertension; Risk factors; Exaggerated blood pressure response. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013000400368 |
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