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	Provedor de dados BABT (2) Autor Cardoso,Valbert Nascimento (2) Oliveira,Mônica Cristina de (2) Abrantes,Fabiana Moreira (1) Carmo,Vildete Aparecida Sousa (1) Carvalho Júnior,Álvaro Dutra de (1) Ferreira,Raphael Ligório Benedito (1) Freire,Luís Paulo (1) Leal,Alexandre Soares (1) Menezes,Maria Ângela (1) Mota,Luciene das Graças (1) Mais... Palavra-chave 99mTechnetium (1) Biodistribution (1) Infection imaging (1) PH-sensitive liposomes (1) Radiolabelled cisplatin (1) Scintigraphy (1) TRIGA research reactor (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2007 (1) 2005 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Use of labelled cisplatin obtained by direct irradiation in a preliminary biodistribution study BABT Carvalho Júnior,Álvaro Dutra de; Abrantes,Fabiana Moreira; Menezes,Maria Ângela; Leal,Alexandre Soares; Cardoso,Valbert Nascimento; Oliveira,Mônica Cristina de. This work presents the preparation of radiolabelled cis-dichlorodiammineplatinum (II), CDDP*, from its direct irradiation into a cadmium capsule, using the TRIGA MARK I IPR R-1 research reactor of the CDTN. The ability to detect CDDP* in Ehrlich tumour-bearing mice after administration via an intravenous route was evaluated. After 24 hours, blood and some organs were collected to determine the incorporated activity. The CDDP* showed a great chemical purity and high specific activity that resulted in an optimum in vivo detection. The CDDP* was taken up principally by liver, spleen and kidney. The CDDP* obtained from this condition was shown to be a good tool for biodistribution studies. Tipo: Info:eu-repo/semantics/article Palavras-chave: Radiolabelled cisplatin; Biodistribution; TRIGA research reactor. Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132005000700013 Technetium-99m-labeled stealth pH-sensitive liposomes: a new strategy to identify infection in experimental model BABT Carmo,Vildete Aparecida Sousa; Oliveira,Mônica Cristina de; Mota,Luciene das Graças; Freire,Luís Paulo; Ferreira,Raphael Ligório Benedito; Cardoso,Valbert Nascimento. The diagnosis of inflammatory and infectious processes is an important goal in medicine. The use of radiopharmaceuticals for identification of inflammation and infection foci has received considerable attention. The aim of this work was to evaluate the uptake and the imaging potential of stealth pH-sensitive liposomes radiolabelled with 99mTechnetium (99mTc) to identify infection sites in mice. The liposomes containing glutathione were labeled with 99mTc-Hexamethylpropyleneamine oxime (HMPAO) complex. The 99mTc-labeled stealth pH-sensitive liposomes (99mTc-SpHL) were injected in mice bearing infection in the right thigh muscle induced by Staphylococcus aureus. Biodistribution studies and scintigraphic imaging were performed at different times after... Tipo: Info:eu-repo/semantics/article Palavras-chave: 99mTechnetium; PH-sensitive liposomes; Infection imaging; Scintigraphy. Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132007000600025 Registros recuperados: 2 Primeira ... 1 ... Última

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