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| Olivero-Verbel,Jesús; Guerrero-Castilla,Angélica; Stashenko,Elena. |
| The essential oil (EO) of Lippia alba (Mill.) N. E. Brown (Verbenaceae) has been traditionally used to treat several diseases. In this study, the acute toxic effects of the citral chemotype of L. alba EO were evaluated in mice. Animals were treated via intraperitoneal receiving the L. alba essential oil at doses between 50 and 2500 mg/kg, and the control group received sesame oil (vehicle). The EO induced dose-dependent neurotoxic effects at doses greater than 1000 mg/kg, including decreased locomotion, motor skills and muscle strength, hypotonia, dyspnea, kyphosis and convulsions. The EO was lethal at a dose of 2500 mg/kg. Animals receiving 1000 mg/kg were euthanized at the end of the treatment period and their blood and livers were collected for... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Essential oil; Lippia alba; Neurological damage; Acute toxicity. |
| Ano: 2010 |
URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S1851-37432010000100003 |
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| Arroyo-Salgado,Bárbara; Olivero-Verbel,Jesús; Guerrero-Castilla,Angélica. |
| ABSTRACT Contact with the pesticide dichlorodiphenyltrichloroethane (p,p′-DDT) can be the cause of various harmful effects in humans, wildlife, and the environment. This pesticide is known to be persistent, lipophilic, resistant to degradation, and bioaccumulive in the environment and to be slowly released into bloodstream. Growing evidence shows that exposure to DDT is linked to type 2 diabetes mellitus. Individuals exposed to elevated levels of DDT and its metabolite have an increased prevalence of diabetes and insulin resistance. To evaluate these possible relationships, experiments were performed on eight-week-old female mice, divided into three groups (n = 10 per group): Group 1 received a vehicle-control intraperitoneal (i.p.) injection of sesame... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Pesticides; Persistent organic pollutant; Dichlorodiphenyltrichloroethane/exposure; Type 2 diabetes mellitus/exposure to dichlorodiphenyltrichloroethane/experimental study; Insulin/resistance/exposure to dichlorodiphenyltrichloroethane; Gene expression. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502016000200287 |
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