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	Provedor de dados BJMBR (2) Autor Nonoyama,K. (2) Oshiro,M. (2) Barretto,O.C. de O. (1) Barretto,O.C.O. (1) Ebner-Filho,W. (1) Fedullo,J.D.L. (1) Medeiros,T.M.D. (1) Miguita,K. (1) Oliveira,R.A.G. (1) Poli-Neto,A. (1) Watanabe,C.I. (1) Mais... Palavra-chave Didelphis marsupialis (1) Erythrocyte glucose-6-phosphate dehydrogenase (1) Erythrocyte glutathione (1) F cells (1) Fetal hemoglobin (1) HIV1/2 (1) Hemoglobin (1) Human immunodeficiency virus (1) Zidovudine (1) Mais... Tipo do documento Info:eu-repo/semantics/other (2) Ano 2006 (1) 2000 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Erythrocyte glucose-6-phosphate dehydrogenase from Brazilian opossum Didelphis marsupialis BJMBR Barretto,O.C. de O.; Oshiro,M.; Oliveira,R.A.G.; Fedullo,J.D.L.; Nonoyama,K.. In a comparative study of erythrocyte metabolism of vertebrates, the specific activity of glucose-6-phosphate dehydrogenase (G6PD) of the Brazilian opossum Didelphis marsupialis in a hemolysate was shown to be high, 207 ± 38 IU g-1 Hb-1 min-1 at 37ºC, compared to the human erythrocyte activity of 12 ± 2 IU g-1 Hb-1 min-1 at 37ºC. The apparent high specific activity of the mixture led us to investigate the physicochemical properties of the opossum enzyme. We report that reduced glutathione (GSH) in the erythrocytes was only 50% higher than in human erythrocytes, a value lower than expected from the high G6PD activity since GSH is maintained in a reduced state by G6PD activity. The molecular mass, determined by G-200 Sephadex column chromatography at pH 8.0,... Tipo: Info:eu-repo/semantics/other Palavras-chave: Erythrocyte glucose-6-phosphate dehydrogenase; Didelphis marsupialis; Erythrocyte glutathione. Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000500007 Increased fetal hemoglobin levels in patients infected with human immunodeficiency virus (HIV1/2) BJMBR Poli-Neto,A.; Nonoyama,K.; Oshiro,M.; Ebner-Filho,W.; Miguita,K.; Medeiros,T.M.D.; Watanabe,C.I.; Barretto,O.C.O.. Fetal hemoglobin was measured in HIV1/2 patients under treatment with combined therapy (zidovudine and a protease inhibitor). A total of 143 patients and 103 normal individuals were investigated by the quantitative method of Betke and the semi-quantitative acid elution method of Kleihauer. In the normal person, hemoglobin F makes up less than 1% and an increase higher than 1.5% was observed in 21.4% of HIV patients by the method of Betke and in 24.8% of HIV-infected patients by the method of Kleihauer. The quantitative biochemical method of Betke showed that the populations were significantly different (two-tailed Mann-Whitney test). The reason for this hemoglobin F increase might be ascribed to the effect of zidovudine or to direct viral action on gamma... Tipo: Info:eu-repo/semantics/other Palavras-chave: Human immunodeficiency virus; HIV1/2; Hemoglobin; Fetal hemoglobin; F cells; Zidovudine. Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000001100008 Registros recuperados: 2 Primeira ... 1 ... Última

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