|
|
| Ramírez,Mario A.; Pérez,Herminia I.; Manjarrez,Norberto; Solís,Aida; Luna,Héctor; Cassani,Julia. |
| Chiral diarylmethanols are versatile building blocks for the preparation of biologically active substances, but they are difficult to obtain in enantiopure form. We used Nocardia corallina B-276 for the oxidative kinetic resolution of (±)-4-(chlorophenyl)phenylmethanol, 1. Two experimental methods were used: 1) Suspension of cells in a phosphate buffer solution and 2) Cells in the culture media, in a 3-L bioreactor. After 36 hrs using the first method, the ketone/alcohol ratio was 56/44 and the unoxidized alcohol had an enantiomeric ratio of 93/7, predominating the R-alcohol. |
| Tipo: Journal article |
Palavras-chave: 4-chlorobenzophenone; Biocatalysis; Microbial oxidation; Resolution. |
| Ano: 2008 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-34582008000400002 |
| |
