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	Provedor de dados Anais da ABC (AABC) (2) Autor FIGUEIREDO,CLAUDIA P. (2) PASSOS,GISELLE F. (2) CHIARADIA-DELATORRE,LOUISE D. (1) CLARKE,JULIA R. (1) CORDEIRO,YRAIMA (1) COSTA,ROBSON DA (1) FERREIRA,NATALIA C. (1) MACHADO,CLARICE S.C. (1) MASCARELLO,ALESSANDRA (1) NEUENFELDT,PATRÍCIA D. (1) NEVES,FERNANDA S. (1) NUNES,RICARDO J. (1) SOUSA,RICARDO A.L. DE (1) TORRES,YASMIN S. (1) Mais... Palavra-chave Acute toxicity (1) Depression (1) Drug safety (1) Hippocampus (1) Inflammation (1) Insulin resistance (1) Learning (1) Memory (1) Organic compound (1) Pharmacokinetics (1) Prion (1) Programing (1) Scrapie (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2018 (1) 2015 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Toxicological Evaluation of Anti-Scrapie Trimethoxychalcones and Oxadiazoles Anais da ABC (AABC) FIGUEIREDO,CLAUDIA P.; FERREIRA,NATALIA C.; PASSOS,GISELLE F.; COSTA,ROBSON DA; NEVES,FERNANDA S.; MACHADO,CLARICE S.C.; MASCARELLO,ALESSANDRA; CHIARADIA-DELATORRE,LOUISE D.; NEUENFELDT,PATRÍCIA D.; NUNES,RICARDO J.; CORDEIRO,YRAIMA. An altered form of the cellular prion protein, the PrPScor PrPRes, is implicated in the occurrence of the still untreatable transmissible spongiform encephalopathies. We have previously synthesized and characterized aromatic compounds that inhibit protease-resistant prion protein (PrPRes) accumulation in scrapie-infected cells. These compounds belong to different chemical classes, including acylhydrazones, chalcones and oxadiazoles. Some of the active compounds were non-toxic to neuroblastoma cells in culture and seem to possess drugable properties, since they are in agreement with the Lipinski´s rule of 5 and present desirable pharmacokinetic profiles as predicted in silico. Before the evaluation of the in vivo efficacy of the aromatic compounds in... Tipo: Info:eu-repo/semantics/article Palavras-chave: Prion; Acute toxicity; Organic compound; Drug safety; Scrapie; Pharmacokinetics. Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652015000301421 Consequences of gestational diabetes to the brain and behavior of the offspring Anais da ABC (AABC) SOUSA,RICARDO A.L. DE; TORRES,YASMIN S.; FIGUEIREDO,CLAUDIA P.; PASSOS,GISELLE F.; CLARKE,JULIA R.. ABSTRACT Gestational diabetes mellitus (GD) is a form of insulin resistance triggered during the second/third trimesters of pregnancy in previously normoglycemic women. It is currently estimated that 10% of all pregnancies in the United States show this condition. For many years, the transient nature of GD has led researchers and physicians to assume that long-term consequences were absent. However, GD diagnosis leads to a six-fold increase in the risk of developing type 2 diabetes (T2D) in women and incidence of obesity and T2D is also higher among their infants. Recent and concerning evidences point to detrimental effects of GD on the behavior and cognition of the offspring, which often persist until adolescence or adulthood. Considering that the... Tipo: Info:eu-repo/semantics/article Palavras-chave: Insulin resistance; Hippocampus; Inflammation; Depression; Learning; Memory; Programing. Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000502279 Registros recuperados: 2 Primeira ... 1 ... Última

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