|
|
|
|
| |
|
| |
|
|
| POLI, P.; MELLO, M. A. de; BUSCHINI, A.; CASTRO, V. L. S. S. de; RESTIVO, F. M.; ROSSI, C.; ZUCCHI, T. M. A. D.. |
| Fenarimol, a systemic pyrimidine carbinol fungicide, is considered to be not genotoxic or weakly genotoxic, although the available toxicological data are controversial and incomplete. Our results obtained in vitro with leukocytes of two different rodent species (rat and mouse) show that fenarimol affects DNA, as detected by the single-cell gel electrophoresis (SCGE, Comet) assay. This fungicide is able to induce DNA damage in a dose-related manner, with significant effectiveness at 36 nM, but without significant interspecies differences. Simultaneous exposure of rat leukocytes to fenarimol (36-290nM) and a model genotoxic compound (50 ?g/ml bleomycin) produced a supra-additive cytotoxic and genotoxic effect. This supports previous findings suggesting... |
| Tipo: Artigo de periódico |
Palavras-chave: Fungicida; Análise química; Eletroforese; Toxidez.. |
| Ano: 2003 |
URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/15095 |
| |
|
| |
|
|
|
