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Histatin 5 and human lactoferrin inhibit biofilm formation of a fluconazole resistant Candida albicans clinical isolate Anais da ABC (AABC)
CURVELO,JOSÉ A.R.; MORAES,DANIEL C. DE; ANJOS,CAMILA A. DOS; PORTELA,MARISTELA B.; SOARES,ROSANGELA M.A..
Abstract:Candida albicans is the most important fungal pathogen that causes infections in humans. Biofilms are hard-to-treat structures due to their high antifungal resistance. Saliva is a fluid that contains antimicrobial substances acting as the first-line of defense against pathogens, and its immune components may be potential tools for the discovery of new treatments against candidiasis. To evaluate the activity of histatin 5 and human lactoferrin against biofilm formation. A fluconazole-resistant Candida albicans clinical isolate was used as the model microorganism. Morphogenesis was evaluated by differential counting. Biofilm quantification was performed by XTT reduction assay. Thickness and topography of biofilms were assessed through confocal laser...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Biofilm; Candida albicans; Fluconazole resistance; Histatin 5; Lactoferrin.
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000100622
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