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| Santos,Damião Carlos Moraes dos; Martinho,José Manoel da Silva Gomes; Pacheco-Moreira,Lucio Filgueiras; Araújo,Cristina Carvalho Viana de; Oliveira,Barbara Cristina Euzebio Pereira Dias de; Lago,Barbara Vieira; Pinto,Marcelo Alves; Paula,Vanessa Salete de. |
| Fulminant hepatic failure (FHF) is characterized by massive hepatocellular injury, whose physiopathology is still unclear. Hepatitis B (HBV) is probably the most common viral cause of FHF, while hepatitis A (HAV) virus seem occurs less frequently. However, the host and viral factors that determine the outcome of these infections are poorly understood. In the present study, viral load and genotyping determining regions of HAV and HBV genomes were sequenced. Eight FHF patients and one patient with severe acute hepatitis (SAH) were included. Liver and blood samples were collected during liver transplantation or necropsy procedures. HAV-RNA and HBV-DNA were extracted from serum, biopsy and paraffin liver. Nucleotide sequencing of HAV-RNA was performed from... |
| Tipo: Info:eu-repo/semantics/report |
Palavras-chave: Fulminant hepatitis failure; Hepatitis A virus (HAV); Hepatitis B virus (HBV) and genotype and viral load. |
| Ano: 2009 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000500002 |
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