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| Bonfim,Mariana Rotta; Camargo Filho,José Carlos Silva; Vanderlei,Luiz Carlos Marques; Padulla,Susimary Aparecida Trevizan; Accioly,Marilita Falângola; Souza,Dorotéia Rossi Silva; Azoubel,Reinaldo. |
| Physical exercise and statins, which are recommended for the treatment of dyslipidemia, are independently associated to the occurrence of muscle injury. The objective is analyze the effect of aerobic exercise associated to the use of simvastatin on the morphology of the gastrocnemius muscle. Thirty Wistar rats were divided into six groups, two of which received a standard diet (1 sedentary and 1 exercised) and four (1 sedentary with medication, 1 sedentary without medication, 1 exercised with medication, 1 exercised without medication) received a hypercholesterolemic diet (standard diet with the addition of cholesterol and coconut oil). Simvastatin (20 mg/Kg) was administered five days a week for eight weeks, together with aerobic training on a treadmill... |
| Tipo: Journal article |
Palavras-chave: Hydroxymethylglutaryl-CoA Reductase Inhibitors; Exercise; Skeletal Muscle. |
| Ano: 2009 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022009000400031 |
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| Accioly,Marilita Falângola; Souza,Dorotéia Rossi Silva; Padulla,Susimary Aparecida Trevizan; Camargo Filho,José Carlos Silva; do Carmo,Edna Maria; Martins,Alex Tadeu; Brandão,Antônio Carlos; Azoubel,Reinaldo. |
| The present study was carried out to evaluate the effect of statins associated with physical exercise (PE) in liver cells in dyslipidemic rats through cariometry. The animals were divided into six groups: animals subjected to a hypercholesterolemic diet (HD), simvastatin, with (G1) and without (G2) physical exercise (PE); HD submitted (G3) or not (G4) to PE, and commercial food diet (F) with (G5) and without (G6) PE. Histological analysis of the liver was performed by staining the slides with hematoxylin and eosin. The cariometric study included measuring the major and minor diameters of the hepatocytes nuclei. The Shapiro-Wilk test was also performed. To determine the differences among the groups, the Kruskal-Wallis Test with Dunn's post-test were... |
| Tipo: Journal article |
Palavras-chave: Simvastatin; Exercise; Diet; Cariometry. |
| Ano: 2013 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022013000400026 |
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| Padulla,Susimary Aparecida Trevizan; Azoubel,Reinaldo; Bonfim,Mariana Rotta; Accioly,Marilita Falángola; Camargo Filho,José Carlos Silva; Padovani,João Armando; Brandao,Antonio Carlos; Souza,Dorotéia Rossi Silva. |
| Physical exercise and statins, recommended interventions to dyslipidaemia treatment, are independently related to cardiomyocytes alterations, characterized by miocardic hypertrophy and apoptosis, respectively. Thus, the objective of the present study was to analyze the effects of statin and aerobic physical exercise association in the morphometric parameters of cardiac cell nucleus. 40 male rats adults were divided into four groups: exercised (DE); sedentary (DS), exercised and statin use (DES); sedentary and statin use (DSS). The animals received during the whole experimental period a hiperlipidic diet added 20% of coconut oil and 1.25% of cholesterol; after 30 days of its ingestión, a blood collection was made to verify the dyslipidaemia. Simvastatin (20... |
| Tipo: Journal article |
Palavras-chave: Hydroxymethylglutaryl-CoA Reductase Inhibitors; Exercise; Cardiomyocite nuclei. |
| Ano: 2009 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022009000100015 |
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