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| Pardini,V.C.; Mourão,D.M.; Nascimento,P.D.; Vívolo,M.A.; Ferreira,S.R.G.; Pardini,H.. |
| Type 1 diabetes, as an autoimmune disease, presents several islet cell-specific autoantibodies such as islet cell antibody (ICA), anti-insulin, anti-glutamic acid decarboxylase (GAD) and the antibody (Ab) against tyrosine phosphatase (PTP)-like protein known as ICA-512 (IA-2). In order to determine the frequency of the anti-GAD and anti-IA-2 autoantibodies in Brazilian type 1 diabetes patients we studied 35 diabetes mellitus (DM) type 1 patients with recent-onset disease (<FONT FACE="Symbol">£</font>12 months) and 37 type 1 diabetes patients with long-duration diabetes (>12 months) who were compared to 12 children with normal fasting glucose. Anti-GAD65 and anti-IA-2 autoantibodies were detected with commercial immunoprecipitation... |
| Tipo: Info:eu-repo/semantics/other |
Palavras-chave: Type 1 diabetes; Autoimmunity; GAD and IA-2 autoantibodies. |
| Ano: 1999 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999001000003 |
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| Pardini,V.C.; Victória,I.M.N.; Pieroni,F.B.; Milagres,G.; Nascimento,P.D.; Velho,G.; Purisch,S.; Pardini,H.. |
| We have investigated the relationship between fetal hemoglobin (HbF) levels and metabolic control in subjects with insulin-dependent (N = 79) and non-insulin-dependent diabetes mellitus (N = 242). HbF and hemoglobin A1c (HbA1c) levels were increased in subjects with type 1 and type 2 diabetes as compared to levels in nondiabetic individuals (P<0.0001), and were significantly higher in type 1 than in type 2 diabetes subjects. Lower levels of HbA1c and HbF were observed in type 2 diabetes subjects treated by diet, intermediate levels in those treated with oral hypoglycemic agents, and higher levels in those treated with insulin. HbF and HbA1c levels were correlated in type 1 diabetes (R2 = 0.57, P<0.0001) and type 2 diabetes (R2 = 0.58,... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Fetal hemoglobin; HbA1c; Glycated hemoglobin; Diabetes mellitus; Type 1 diabetes; Type 2 diabetes. |
| Ano: 1999 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000600005 |
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