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	Provedor de dados Biocell (1) Autor Hong,Samin (1) Kim,Chan Yun (1) Park,Kyoungsoo (1) Seong,Gong Je (1) Palavra-chave Agmatine (1) Hypoxia (1) Retinal ganglion cell (1) Tumor necrosis factor-alpha (1) Tipo do documento Info:eu-repo/semantics/other (1) Ano 2008 (1) País Argentina (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Agmatine inhibits hypoxia-induced TNF-alpha release from cultured retinal ganglion cells Biocell Hong,Samin; Park,Kyoungsoo; Kim,Chan Yun; Seong,Gong Je. The effect of hypoxia on the release of tumor necrosis factor-alpha (TNF-alpha) in transformed rat retinal ganglion cells (RGCs) and the effect of agmatine on the hypoxia-induced production of TNF-alpha in RGCs were evaluated. RGCs were cultured under hypoxic conditions with 5% oxygen, with or without 100μM agmatine. The expression levels of TNF-alpha and its receptor-1 (TNF-R1) were investigated by Western blot analysis. After 6 hours of hypoxia, we noted an increase in TNF-alpha production in RGCs. Agmatine significantly reduced TNF-alpha level after 12 hours of hypoxic treatment. The expression of TNF-R1 was not affected by the hypoxia or agmatine treatment. Our results show that agmatine inhibits the TNF-alpha production of RGCs in hypoxic... Tipo: Info:eu-repo/semantics/other Palavras-chave: Retinal ganglion cell; Tumor necrosis factor-alpha; Hypoxia; Agmatine. Ano: 2008 URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0327-95452008000200006 Registros recuperados: 1 Primeira ... 1 ... Última

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