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	Provedor de dados BJPS (2) Autor Cordeiro,Everson Willian Fialho (2) Malesuik,Marcelo Donadel (2) Paim,Clésio Soldateli (2) Paula,Fávero Reisdorfer (2) Bairros,André Valle de (1) Batista,Luiz Alcides das Chagas (1) Hilgert,Renata Medeiros (1) Machado,Michel Mansur (1) Oliveira,Luís Flávio Souza de (1) Pereira,Danillo Baptista (1) Silva,Fabiana Ernestina Barcellos da (1) Souza,Raul Oliveira (1) Stopiglia,Cheila Denise Ottonelli (1) Mais... Palavra-chave Biological safety (1) Danofloxacin (1) Fluoroquinolones photodegradation (1) Fluoroquinolones/evaluation (1) Forced degradation studies (1) In silico toxicology (1) Microbiological assay (1) Molecular modeling (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2020 (1) 2018 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Evaluation of the influence of fluoroquinolone chemical structure on stability: forced degradation and in silico studies BJPS Bairros,André Valle de; Pereira,Danillo Baptista; Cordeiro,Everson Willian Fialho; Paim,Clésio Soldateli; Silva,Fabiana Ernestina Barcellos da; Malesuik,Marcelo Donadel; Paula,Fávero Reisdorfer. ABSTRACT Fluoroquinolones are a known antibacterial class commonly used around the world. These compounds present relative stability and they may show some adverse effects according their distinct chemical structures. The chemical hydrolysis of five fluoroquinolones was studied using alkaline and photolytic degradation aiming to observe the differences in molecular reactivity. DFT/B3LYP-6.31G* was used to assist with understanding the chemical structure degradation. Gemifloxacin underwent degradation in alkaline medium. Gemifloxacin and danofloxacin showed more degradation perceptual indices in comparison with ciprofloxacin, enrofloxacin and norfloxacin in photolytic conditions. Some structural features were observed which may influence degradation, such... Tipo: Info:eu-repo/semantics/article Palavras-chave: Fluoroquinolones/evaluation; Forced degradation studies; Molecular modeling. Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000100604 Validation of an analytical method by high-performance liquid chromatography and microbiological assay, biological safety and in silico toxicity for danofloxacin BJPS Cordeiro,Everson Willian Fialho; Hilgert,Renata Medeiros; Batista,Luiz Alcides das Chagas; Souza,Raul Oliveira; Oliveira,Luís Flávio Souza de; Machado,Michel Mansur; Malesuik,Marcelo Donadel; Paula,Fávero Reisdorfer; Stopiglia,Cheila Denise Ottonelli; Paim,Clésio Soldateli. Danofloxacin is a veterinary fluoroquinolone used to treat respiratory and gastrointestinal diseases of birds, pigs and cattle. The literature reviewed shows some analytical methods to quantify this fluoroquinolone, but microbiological and biological safety studies are limited. The analytical methods were validated by the Official Codes. The LC-DAD method was developed and validated using an RP-18 column, mobile phase containing a mixture of 0.3% triethylamine (pH 3.0) and acetonitrile (85:15, v/v). The microbiological assay was performed by agar diffusion method (3 x 3) and Staphylococcus epidermidis as a microorganism test. Forced degradation studies were performed in both methods. The minimum inhibitory concentration (MIC) was performed by test... Tipo: Info:eu-repo/semantics/article Palavras-chave: Danofloxacin; Microbiological assay; Biological safety; In silico toxicology; Fluoroquinolones photodegradation. Ano: 2020 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100555 Registros recuperados: 2 Primeira ... 1 ... Última

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