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| Magalhães,H.R.; Leite,S.B.P.; Paz,C.C.P. de; Duarte,G.; Ramos,E.S.. |
| In addition to methylated cytosines (5-mCs), hydroxymethylcytosines (5-hmCs) are present in CpG dinucleotide-enriched regions and some transcription regulator binding sites. Unlike methylation, hydroxymethylation does not result in silencing of gene expression, and the most commonly used methods to study methylation, such as techniques based on restriction enzymatic digestion and/or bisulfite modification, are unable to distinguish between them. Genomic imprinting is a process of gene regulation where only one member of an allelic pair is expressed depending on the parental origin. Chromosome 11p15.5 has an imprinting control region (ICR2) that includes a differentially methylated region (KvDMR1) that guarantees parent-specific gene expression. The... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Methylation; Hydroxymethylation; Placenta; Genomic Imprinting; ICR2; KvDMR1. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013001100916 |
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