|
|
| Miranda-Vilela,Ana L.; Akimoto,Arthur K.; Alves,Penha C.Z.; Hiragi,Cássia O.; Penalva,Guilherme C.; Oliveira,Silviene F.; Grisolia,Cesar K.; Klautau-Guimarães,Maria N.. |
| Haptoglobin is a plasma hemoglobin-binding protein that limits iron loss during normal erythrocyte turnover and hemolysis, thereby preventing oxidative damage mediated by iron excess in the circulation. Haptoglobin polymorphism in humans, characterized by the Hp*1 and Hp*2 alleles, results in distinct phenotypes known as Hp1-1, Hp2-1 and Hp2-2, whose frequencies vary according to the ethnic origin of the population. The Hp*1 allele has two subtypes, Hp*1F and Hp*1S, that also vary in their frequencies among populations worldwide. In this work, we examined the distribution frequencies of haptoglobin subtypes in three Brazilian population groups of different ethnicities. The haptoglobin genotypes of Kayabi Amerindians (n = 56), Kalunga Afro-descendants (n =... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Brazilian ethnicities; Haptoglobin; Polymorphism; Subtypes. |
| Ano: 2009 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572009000300005 |
| |
