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| Goveia,Vania Regina; Pinto,Flavia Morais Gomes; Machoshvili,Irene Alexeevna; Penna,Thereza Christina Vessoni; Graziano,Kazuko Uchikawa. |
| It is estimated that electric drills (ED) have been used in orthopaedic surgeries for bone drilling for more than 50 years in Brazilian hospitals. It is an electric, thermosensitive equipment, not indicated for surgical use, which has not been previously evaluated regarding the sterilization efficacy, being suspect of infection risk. This study evaluated the efficacy of sterilization by ethylene oxide (EtO) of new drills that were intentionally contaminated with Bacillus atrophaeus spores. An experimental, laboratory, randomized applied research was developed, where 16 electric drills were analyzed, in addition to positive and negative controls. All the previously cleaned and sterilized equipment were submitted to contamination by spores. The experimental... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Sterilization; Orthopaedic surgery; Surgical wound infection; Orthopaedic equipment; Ethylene oxide. |
| Ano: 2009 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822009000300016 |
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| Santos,Carolina Alves dos; Oliveira-Nascimento,Laura; Knirsch,Marcos Camargo; Stephano,Marco Antônio; Pessoa Júnior,Adalberto; Penna,Thereza Christina Vessoni. |
| Ceftazidime is a broad spectrum antibiotic administered mainly by the parenteral route, and it is especially effective against Pseudomonas aeruginosa. The period of time in which serum levels exceed the Minimum Inhibitory Concentration (MIC) is an important pharmacodynamic parameter for its efficacy. One of the forms to extend this period is to administer the antibiotic by continuous infusion, after prior dilution in a Parenteral Solution (PS). The present work assessed the stability of ceftazidime in 5% glucose PS for 24 hours, combined or not with aminophylline, through High Performance Liquid Chromatography (HPLC). The physicochemical evaluation was accompanied by in vitro antimicrobial activity compared MIC test in the 24-hour period. Escherichia coli... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Drug/interactions; Injectables; Parenteral solutions; Ceftazidime/stability; Aminophylline/stability; High Performance Liquid Chromatography/quantitative analysis; Minimum inhibitory concentration (MIC). |
| Ano: 2012 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502012000400013 |
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| Santos,Carolina Alves dos; Mazzola,Priscila Gava; Polacwiecz,Bronislaw; Knirsch,Marcos Camargo; Cholewa,Olívia; Penna,Thereza Christina Vessoni. |
| Parenteral solutions (PS) are one of the most commonly used drug delivery vehicles. Interactions among the drug, components in the drug's formulation, and the PS can result in the formation of inactive complexes that limit efficacy or increase side effects. The aim of this work was to evaluate possible interactions between the drugs and PS, assess drug stability and to identify degradation products after 20 h at room temperature. Furosemide (FSM) and Aminophylline (APN) were added to PS containing either 20% mannitol or 0.9% NaCl at pH 6.5-7.5 and 10-11. Their behavior was studied individually and as an admixture, after 1 h oxidation with H2O2, using a spectrophotometer and HPLC. Individually, FSM and APN added to 20% mannitol and 0.9% NaCl solutions had... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Parenteral solutions; Spectrophotometer; High Performance Liquid Chromatography; Furosemide; Aminophylline. |
| Ano: 2011 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000100011 |
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