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	Provedor de dados BABT (1) BJPS (1) Autor Pereira,Eduardo Manoel (2) Bazzo,Giovana Carolina (1) Becker,Ana Cláudia (1) Benetti,Cibele Nabhan (1) Crenca,Janine Paula (1) Dellagnelo,Viviane Aparecida (1) Macedo,Aline Teixeira de (1) Pezzini,Bianca Ramos (1) Rodrigues,Patrik Oening (1) Silva,Marcos Antonio Segatto (1) Silva,Virgínia Emiliana (1) Wagner,Theodoro Marcel (1) Zétola,Melissa (1) Mais... Palavra-chave Anti-inflammatory activity (1) Bioavailability (1) Dexamethasone acetate (1) Drugs/controlled release (1) Drugs/in vitro study (1) Drugs/in vivo evaluation (1) Ibuprofen/release (1) Microspheres/preparation (1) Poly(hydroxybutyrate-co-hydroxyvalerate) (1) Poly(l-lactide) (1) Solubility (1) Β-cyclodextrin (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2014 (1) 2012 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Pharmacodynamic and Pharmacokinetic Studies of β-Cyclodextrin:Dexamethasone Acetate Complexes in Mice BABT Rodrigues,Patrik Oening; Becker,Ana Cláudia; Dellagnelo,Viviane Aparecida; Benetti,Cibele Nabhan; Pereira,Eduardo Manoel; Wagner,Theodoro Marcel; Silva,Marcos Antonio Segatto. The aim of this study was to evaluate the in vivo activity of the anti-inflammatory and analgesic effects of a suspension of the complex composed of dexamethasone acetate (DMA) with β-cyclodextrin in comparison to a suspension of the pure DMA. Solid complexes prepared by different methods were evaluated in pharmacodynamics and pharmacokinetics studies. The pharmacodynamic effect was investigated although the capacity of the inhibited the inflammation. Models of abdominal constriction, carrageenan-induced paw oedema and formalin induced licking were used. The study of the pharmacodynamic comparison of free DMA and products of β-CD:DMA demonstrated no significant difference in the majority of the tests performed. Plasma concentrations of DMA and DMA:β-CD... Tipo: Info:eu-repo/semantics/article Palavras-chave: Solubility; Dexamethasone acetate; Β-cyclodextrin; Bioavailability; Anti-inflammatory activity. Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132014000600887 Microspheres prepared with biodegradable PHBV and PLA polymers as prolonged-release system for ibuprofen: in vitro drug release and in vivo evaluation BJPS Bazzo,Giovana Carolina; Macedo,Aline Teixeira de; Crenca,Janine Paula; Silva,Virgínia Emiliana; Pereira,Eduardo Manoel; Zétola,Melissa; Pezzini,Bianca Ramos. In this study, poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV) and poly(l-lactide) (PLA) microspheres containing ibuprofen were prepared with the aim of prolonging the drug release. The oil-in-water (O/W) emulsion solvent evaporation technique was used, varying the polymer ratio. All formulations provided spherical particles with drug crystals on the surface and a porous and rough polymeric matrix when PHBV was used and smooth external surface when prepared with PLA. The in vitro dissolution profiles show that the formulation containing PHBV/PLA at the proportion of 30/70 presented the best results in terms of prolonging the ibuprofen release. The analysis of the concentration of ibuprofen in the blood of rats showed that maximum levels were achieved at... Tipo: Info:eu-repo/semantics/article Palavras-chave: Microspheres/preparation; Poly(hydroxybutyrate-co-hydroxyvalerate); Poly(l-lactide); Ibuprofen/release; Drugs/controlled release; Drugs/in vitro study; Drugs/controlled release; Drugs/in vivo evaluation. Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502012000400021 Registros recuperados: 2 Primeira ... 1 ... Última

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