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VEGF receptor expression decreases during lung development in congenital diaphragmatic hernia induced by nitrofen BJMBR
Sbragia,L.; Nassr,A.C.C.; Gonçalves,F.L.L.; Schmidt,A.F.; Zuliani,C.C.; Garcia,P.V.; Gallindo,R.M.; Pereira,L.A.V..
Changes in vascular endothelial growth factor (VEGF) in pulmonary vessels have been described in congenital diaphragmatic hernia (CDH) and may contribute to the development of pulmonary hypoplasia and hypertension; however, how the expression of VEGF receptors changes during fetal lung development in CDH is not understood. The aim of this study was to compare morphological evolution with expression of VEGF receptors, VEGFR1 (Flt-1) and VEGFR2 (Flk-1), in pseudoglandular, canalicular, and saccular stages of lung development in normal rat fetuses and in fetuses with CDH. Pregnant rats were divided into four groups (n=20 fetuses each) of four different gestational days (GD) 18.5, 19.5, 20.5, 21.5: external control (EC), exposed to olive oil (OO), exposed to...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Congenital diaphragmatic hernia; VEGFR; Rat model; Nitrofen; Lung development.
Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2014000200171
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Ethidium bromide-induced demyelination of the sciatic nerve of adult Wistar rats BJMBR
Riet-Correa,G.; Fernandes,C.G.; Pereira,L.A.V.; Graça,D.L..
Peripheral nerve ultrastructure was assessed after single or multiple local injections of the intercalating dye ethidium bromide. Thirty-four adult Wistar rats of both sexes were divided into five groups and maintained in a controlled environment with rat chow and water ad libitum throughout the experiment. The experimental animals were injected with 1 µl of 0.1% ethidium bromide in 0.9% saline into the central third of the left sciatic nerve 1 (group 1), 2 (group 2), 4 (group 3), 6 (group 4) or 8 (group 5) times. In groups 2 to 5 the injections were made at 28-day intervals. Control animals received the same amount of 0.9% saline. The animals were killed at different times after injection: group 1 at 7 days (2 rats) and 15 days (2 rats); for groups 2, 3,...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Demyelination; Remyelination; Sciatic nerve; Ethidium bromide.
Ano: 2002 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000100014
Registros recuperados: 2
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