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| Gusmão,Karla A. G.; Santos,Daniel M. dos; Santos,Virgílio M.; Cortés,María Esperanza; Reis,Pablo V. M.; Santos,Vera L.; Piló-Veloso,Dorila; Verly,Rodrigo M.; Lima,Maria Elena de; Resende,Jarbas M.. |
| Abstract Background The availability of antimicrobial peptides from several different natural sources has opened an avenue for the discovery of new biologically active molecules. To the best of our knowledge, only two peptides isolated from the frog Leptodactylus labyrinthicus, namely pentadactylin and ocellatin-F1, have shown antimicrobial activities. Therefore, in order to explore the antimicrobial potential of this species, we have investigated the biological activities and membrane interactions of three peptides isolated from the anuran skin secretion. Methods Three peptide primary structures were determined by automated Edman degradation. These sequences were prepared by solid-phase synthesis and submitted to activity assays against gram-positive... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Leptodactylus labyrinthicus; Ocellatins; Antimicrobial peptides; Peptide membrane interactions. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992017000100302 |
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| Abreu,Viviane Gomes da Costa; Silva,Marilda Conceição da; Magalhães,Rozângela Manfrini; Piló-Veloso,Dorila; Xavier,Izelene Felício da Silva; Oliveira,Patrícia Machado; Alcântra,Antônio Flávio de Carvalho. |
| Three coumarins, 5-methoxypsoralene, xanthyletin, and (-)-marmesin, have been isolated from the ethanolic extract of the stem of the Amazonian plant Brosimum potabile. The structures were determined on the basis of NMR analyses and by comparison with spectroscopic data in the literature. The analysis of the hexane fractions by GC-MS in EIMS mode suggested the presence of (1-methylpentyl)-benzene; α,α-dimethyl-4-(1-methylethyl)-benzenemethanol; 1-methyl-3,5-bis(1-methylethyl)-benzene; urs-12-ene; chola-5,22-dien-3β-ol; cholesta-4,6-dien-3β-ol; sitosteryl 9(Z)-octadecenoate; cholesta-5,22-dien-3β-ol; cholesta-4,6,22-trien-3-one; and cholesta-4,22-dien-3-one. NMR data of other hexane fractions indicated the presence of 3β-acetoxy-lup-12,20(29)-diene;... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Brosimum potabile; Coumarins; Pentacyclic triterpenes; Structural characterization by NMR and GC/MS. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0044-59672010000400011 |
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