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| Santini-Oliveira,Marilia; Friedman,Ruth Khalili; Veloso,Valdilea Gonçalves; Cunha,Cynthia Braga; Pilotto,José Henrique; Marins,Luana Monteiro Spindola; João,Esaú Custódio; Torres,Thiago Silva; Grinsztejn,Beatriz. |
| Mother-to-child transmission (MTCT) of human immunodeficiency virus (HIV) infection remains an important cause of new HIV infections worldwide, especially in low and middle-resource limited countries. Safety data from studies involving pregnant women and prenatal antiretroviral (ARV) exposure are still needed once these studies are often small and with a limited duration to assess adverse drug reactions (ADR). The aim of this study was to estimate the incidence of ADR related to the use of antiretroviral therapy (ART) in pregnant women in two referral centers in Rio de Janeiro State. A prospective study was carried out from February 2005 to May 2006. Women were classified according to their ART status during pregnancy diagnosis: ARV-experienced (ARTexp) or... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: HIV; Antiretroviral; Prevention of mother-to-child transmission; Adverse drug reaction; Toxicity. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000400372 |
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| Peixoto,Mario Ferreira; Pilotto,José Henrique; Stoszek,Sonia Karolina; Kreitchmann,Regis; Mussi-Pinhata,Marisa Márcia; Melo,Victor Hugo; João,Esaú Custodio; Ceriotto,Mariana; Souza,Ricardo da Silva de; Read,Jennifer. |
| OBJECTIVES: To describe laboratory abnormalities among HIV-infected women and their infants with standard and increased lopinavir/ritonavir (LPV/r) dosing during the third trimester of pregnancy. METHODS: We evaluated data on pregnant women from NISDI cohorts (2002-2009) enrolled in Brazil, who received at least 28 days of LPV/r during the third pregnancy trimester and gave birth to singleton infants. RESULTS: 164 women received LPV/r standard dosing [(798/198 or 800/200 mg/day) (Group 1)] and 70 increased dosing [(> 800/200 mg/day) (Group 2)]. Group 1 was more likely to have advanced clinical disease and to use ARVs for treatment, and less likely to have CD4 counts > 500 cells/mm³. Mean plasma viral load was higher in Group 2. There were... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Pregnancy; HIV; HIV protease inhibitors; Drug toxicity. |
| Ano: 2011 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000300013 |
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| Araujo,Elaine S. Pires; Friedman,Ruth Khalili; Camacho,Luis Antonio Bastos; Derrico,Monica; Moreira,Ronaldo Ismério; Calvet,Guilherme Amaral; Oliveira,Marília Santini de; Veloso,Valdilea Gonçalves; Pilotto,José Henrique; Grinsztejn,Beatriz. |
| OBJECTIVES: To describe the access to the interventions for the prevention of Human Immunodeficiency Virus (HIV) mother to child transmission and mother to child transmission rates in the outskirts of Rio de Janeiro, from 1999 to 2009.METHODS: This is a retrospective cohort study. Prevention of HIV mother to child transmission interventions were accessed and mother to child transmission rates were calculated.RESULTS: The study population is young (median: 26 years; interquartile range: 22.0-31.0), with low monthly family income (40.4% up to one Brazilian minimum wage) and schooling (62.1% less than 8 years). Only 47.1% (n = 469) knew the HIV status of their partner; of these women, 39.9% had an HIV-seronegative partner. Among the 1259 newborns evaluated,... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: HIV; HIV vertical transmission; Antiretroviral chemoprophylaxis; Cohort studies; Brazil. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000300252 |
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