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| Nakazone,Marcelo A.; De Marchi,Miguel A.; Pinhel,Marcela A.S.; Barros,Carolina F.D.C.; Júlio,Maysa A.F.; Pinheiro,Anielli; Arazi,Simone S.; Hotta,Júlia K.; Hirata,Mário H.; Hirata,Rosario D.C.; Santos,José E. dos; Souza,Dorotéia R.S.. |
| Xanthelasma might be a clinical manifestation of dyslipidemia, a recognized risk factor for coronary artery disease. We investigated the association of apolipoprotein E (APOE HhaI), apolipoprotein B (APOB XbaI and Ins/Del) and LDL receptor (LDLR AvaII and HincII) gene polymorphisms with lipid profiles in 100 Brazilians with xanthelasma and 100 controls. Allele frequencies were similar in both groups. APOE, APOB and LDLR genotypes were not correlated with differences in the serum lipid profile. In individuals with xanthelasma, the APOB D allele was associated with less chance of having increased LDL-cholesterol (O.R. = 0.16, CI95% = 0.03-0.94, p = 0.042). In the control group, the APOB X+ allele was associated with less chance of having both increased total... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Apolipoprotein B; Apolipoprotein E; LDL receptor; Gene polymorphisms; Xanthelasma. |
| Ano: 2009 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572009000200004 |
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