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	Provedor de dados BJMBR (2) Autor Pinto,A.C. (2) Câmara,C.A. (1) Echevarria,A. (1) Esteves,A. (1) Esteves-Souza,A. (1) Figueiredo,D.V. (1) Lima,J.A. (1) Miranda,A.L.P. de (1) Oliveira,A.S. (1) Rezende,C.M. (1) Vargas,M.D. (1) Mais... Palavra-chave Amino-lapachol derivatives (1) Analgesic (1) Anti-inflammatory effec (1) Antinociceptive effect (1) Carpotroche brasiliensis (1) Cyclopentenyl fatty acids (1) Cytotoxicity (1) DNA-interactions (1) DNA-topoisomerase (1) Flacourtiaceae (1) Lapachol (1) Mais... Tipo do documento Info:eu-repo/semantics/article (1) Info:eu-repo/semantics/other (1) Ano 2007 (1) 2005 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Anti-inflammatory and antinociceptive activities of an acid fraction of the seeds of Carpotroche brasiliensis (Raddi) (Flacourtiaceae) BJMBR Lima,J.A.; Oliveira,A.S.; Miranda,A.L.P. de; Rezende,C.M.; Pinto,A.C.. Carpotroche brasiliensis is a native Brazilian tree belonging to the Oncobeae tribe of Flacourtiaceae. The oil extracted from its seeds contains as major constituents the same cyclopentenyl fatty acids hydnocarpic (40.5%), chaulmoogric (14.0%) and gorlic (16.1%) acids found in the better known chaulmoogra oil prepared from the seeds of various species of Hydnocarpus (Flacourtiaceae). These acids are known to be related to the pharmacological activities of these plants and to their use as anti-leprotic agents. Although C. brasiliensis oil has been used in the treatment of leprosy, a disease that elicits inflammatory responses, the anti-inflammatory and analgesic activities of the oil and its constituents have never been characterized. We describe the... Tipo: Info:eu-repo/semantics/article Palavras-chave: Carpotroche brasiliensis; Flacourtiaceae; Cyclopentenyl fatty acids; Anti-inflammatory effec; Analgesic; Antinociceptive effect. Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000700013 Cytotoxic and DNA-topoisomerase effects of lapachol amine derivatives and interactions with DNA BJMBR Esteves-Souza,A.; Figueiredo,D.V.; Esteves,A.; Câmara,C.A.; Vargas,M.D.; Pinto,A.C.; Echevarria,A.. The cytotoxic activity of amino (3a-e), aza-1-antraquinone (4a-e) lapachol derivatives against Ehrlich carcinoma and human K562 leukemia cells was investigated. Cell viability was determined using MTT assay, after 48 (Ehrlich) or 96 h (K562) of culture, and vincristine (for K562 leukemia) and quercetin (for Ehrlich carcinoma) were used as positive controls. The results showed dose-dependent growth-inhibiting activities and that the amino derivatives were active against the assayed cells, whereas the 4a-e derivatives were not. The allylamine derivative 3a was the most active against Ehrlich carcinoma, with IC50 = 16.94 ± 1.25 µM, and against K562 leukemia, with IC50 = 14.11 ± 1.39 µM. The analogous lawsone derivative, 5a, was also active against Ehrlich... Tipo: Info:eu-repo/semantics/other Palavras-chave: Lapachol; Amino-lapachol derivatives; Cytotoxicity; DNA-topoisomerase; DNA-interactions. Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007001000013 Registros recuperados: 2 Primeira ... 1 ... Última

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