|
|
| Marthandan,Shiva; Menzel,Uwe; Priebe,Steffen; Groth,Marco; Guthke,Reinhard; Platzer,Matthias; Hemmerich,Peter; Kaether,Christoph; Diekmann,Stephan. |
| BACKGROUND: Cellular senescence is induced either internally, for example by replication exhaustion and cell division, or externally, for example by irradiation. In both cases, cellular damages accumulate which, if not successfully repaired, can result in senescence induction. Recently, we determined the transcriptional changes combined with the transition into replicative senescence in primary human fibroblast strains. Here, by γ-irradiation we induced premature cellular senescence in the fibroblast cell strains (HFF and MRC-5) and determined the corresponding transcriptional changes by high-throughput RNA sequencing. RESULTS: Comparing the transcriptomes, we found a high degree of similarity in differential gene expression in replicative as well... |
| Tipo: Journal article |
Palavras-chave: Senescence Fibroblasts γ -irradiation Aging Transcriptome analysis DNA repair. |
| Ano: 2016 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602016000100034 |
| |
