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| Registros recuperados: 11 | |
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| Wiens,Astrid; Lenzi,Luana; Venson,Rafael; Pedroso,Maria Lúcia Alves; Correr,Cassyano Januário; Pontarolo,Roberto. |
| The aim of this study was to conduct a cost-utility study of adefovir, entecavir, interferon alpha, pegylated interferon alpha, lamivudine and tenofovir for chronic hepatitis B in the context of Brazilian Public Health Care System. A systematic review was carried out for efficacy and safety. Another review was performed to collect utility data and transition probabilities between health states. A Markov model was developed in a time horizon of 40 years with annual cycles for three groups of: HBeAg positive, HBeAg negative, and all patients. These strategies were compared to a fourth group that received no treatment. Discount rates of 5% were applied and sensitivity analyses were performed. Tenofovir offered the best cost-utility ratio for the three... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Chronic hepatitis B; Economic evaluation; Treatments. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000400006 |
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| Ferreira,Vinicius Lins; Borba,Helena Hiemisch Lobo; Wiens,Astrid; Pedroso,Maria Lucia Alves; Radunz,Vanessa Ferreira de Camargo; Ivantes,Cláudia Alexandra Pontes; Kuniyoshi,Aline Satie Oba; Pontarolo,Roberto. |
| ABSTRACT Background This study aimed to evaluate the clinical effectiveness in terms of sustained virological response and tolerability of available second generation direct-acting antivirals in Brazilian patients. Methods This was a retrospective observational study conducted in six centers in Southern Brazil. The sample comprised adult patients who were chronically infected with hepatitis C virus, regardless of virus genotype, fibrosis stage, or prior treatment. Statistical analysis was performed to compare the effectiveness among the treatments, and also to uncover the factors influencing the achievement of sustained virological response. Results A total of 296 patients were included in the study, with the majority receiving sofosbuvir with... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Brazil; Direct-acting antivirals; Hepatitis C; Observational study. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000300186 |
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| Lenzi,Luana; Wiens,Astrid; Grochocki,Mônica Holtz Cavichiolo; Pontarolo,Roberto. |
| OBJECTIVE: The pandemic of new influenza A (H1N1) has spread rapidly throughout the world, characterized by high transmissibility, but low pathogenicity and virulence. The aim of this study was to understand the pandemic event and available technologies for disease surveillance, prevention, control and management. METHODS: In this retrospective study, we used data from patients in the State of Paraná who had been diagnosed with the disease during the 2009 pandemic. Data were collected from the disease notification form and the study only included patients with confirmed laboratory diagnosis by RT-PCR. RESULTS: We present the epidemiological profile of 4,740 patients that met the inclusion criteria. The variables age, level of schooling and gestational age... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Influenza A virus; H1N1 subtype disease outbreaks causality. |
| Ano: 2011 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000500007 |
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| Wiens,Astrid; Lenzi,Luana; Grochocki,Mônica Cavichiolo; Correr,Cassyano Januário; Pontarolo,Roberto. |
| Treatment for chronic hepatitis B in Brazil are funded by the Ministry of Health and by the state Departments of Health. Clinical protocol and therapeutic guidelines approve the use of adefovir, entecavir, interferon-a, lamivudine, and tenofovir for the treatment of chronic hepatitis B. The aim of this study was to establish the profile of users of these drugs in the state of Paraná. A cross-sectional study was conducted with patients under treatment in Paraná in August 2011. The following data were obtained: gender, hepatitis B used drug, International Classification of Diseases, and regional health unit. The monthly cost of these drugs for the public health system was also calculated. 1,093 patients registered were found, 70% male, and 2.6% co-infected... |
| Tipo: Info:eu-repo/semantics/other |
Palavras-chave: Chronic hepatitis B; Users profile; Treatments; Demographic profile. |
| Ano: 2012 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000400012 |
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| Correr,Cassyano Januário; Pontarolo,Roberto; Souza,Rodrigo Augusto de Paula e; Venson,Rafael; Melchiors,Ana Carolina; Wiens,Astrid. |
| The aim is to evaluate the humanistic outcomes in type 2 diabetic patients by the adoption of pharmacotherapy follow-up in community pharmacies. Controlled, non-randomized, 12-months trial; n=161 patients distributed into control and intervention groups; 6 community pharmacies involved, all in the Curitiba city region, in the state of Paraná were used. The health-related quality of life (HRQoL) and the satisfaction index were determined using both the DQOL assessment tool, which measures HRQoL, and the satisfaction evaluation tool (QSSF). Interventions on 119 negative therapeutic outcomes were done (2.3/patient [SD=1.6]); the most commonly found problems were related to ineffectiveness of pharmacotherapy (68.1%). The Intervention-Group showed a significant... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Diabetes mellitus/type 2/pharmaceutical care; Pharmaceutical care; Community pharmacy; Pharmacists/community action. |
| Ano: 2009 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502009000400027 |
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| Hipólito Júnior,Edson; Halila,Gerusa Clazer; Reis,Walleri Christini Torelli; Guimarães,Matheus Murmel; Guanaes,Laís Danciguer; Pontarolo,Roberto; Correr,Cassyano Januário. |
| ABSTRACT Pharmacists and their pharmacies have been evolving in their roles as health promoters in Brazil. Some examples are the recent legislation reaffirming the role of Brazilian pharmacies as health institutions, rather than having only a commercial profile, giving greater clarity to pharmacists about their roles as health care providers. This evolution came with the recognition that is already seen in other developed countries, confirming the need for the pharmacist as a health promoter, and not simply a dispenser of drugs in society. This study has obtained the profile and activities of community pharmacists, as well as the quality indicators of private community pharmacies throughout the State of Paraná through the application of an online survey... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Pharmaceutical care. Pharmacists/professional practice. Community pharmacy/structure indicators/Paraná State; Brazil.. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000100615 |
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| Sanches,Andréia Cristina Conegero; Correr,Cassyano Januário; Venson,Rafael; Gonçalves,Patrícia Rodrigues; Garcia,Mariana Martins; Piantavini,Mário Sérgio; Pontarolo,Roberto. |
| All patients with Diabetes Mellitus (DM) receive insulin therapy. In this study, we evaluated the efficacy, safety and tolerability of human insulin and insulin analogues. We performed a systematic review of the literature and a meta-analysis according to the Cochrane Collaboration methodology. In the absence of clinical studies comparing insulins, we performed a mixed treatment comparison to establish the differences between the active treatments. We included studies published from 1995 to 2010. HbA1c results, episodes of hypoglycemia and nocturnal hypoglycemia data were extracted and analyzed. Thirty-five randomized clinical trials were selected after examining the abstract and a full text review. These studies included 4,206 patients who received... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Insulins/meta-analysis; Diabetes mellitus/type 1; Insulin/treatment efficacy; Insulin/safety use. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000300011 |
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| Venson,Rafael; Wiens,Astrid; Correr,Cassyano Januário; Pontarolo,Roberto. |
| The objective is to provide an update on the clinical efficacy, safety and tolerability of the use of abatacept for treating rheumatoid arthritis. A systematic review (up to June 2011) followed by meta-analyses was performed. Randomized controlled clinical trials comparing abatacept at a dose of 10 mg/kg with a placebo, both with concomitant methotrexate, were used. Only high- or moderate-quality studies were included. The efficacy was evaluated based on changes in the ACR, DAS and HAQ; safety was assessed based on serious adverse events, serious infections, malignancies and deaths; tolerability was evaluated based on the withdrawals due to adverse events, serious adverse events and lack of efficacy. All these parameters were evaluated within one year of... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Abatacept/efficacy; Rheumatoid arthritis/treatment; Meta-analyses. |
| Ano: 2012 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502012000400022 |
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| Wiens,Astrid; Borba,Helena Hiemisch Lobo; Leonart,Letícia Paula; Tonin,Fernanda Stumpf; Steimbach,Laiza Maria; Araújo,Ariane Gonçalves Silva de; Piazza,Thais; Ferreira,Vinicius Lins; Pontarolo,Roberto. |
| The aim of this study was to evaluate interruption of treatment with biological drugs and tofacitinib due to adverse events in patients with rheumatoid arthritis. A systematic review was performed in the electronic databases MEDLINE, Cochrane, Scopus, CRD, IPA, Lilacs and Scielo. Case reports addressing interruption of treatment due to any adverse event related to abatacept (ABA), adalimumab (ADA), anakinra (ANA), certolizumab pegol (CER), etanercept (ETA), golimumab (GOL), infliximab (IFX), rituximab (RTX), secukinumab (SEC), tocilizumab (TCZ), tofacitinib (TOF) or ustekinumab (UST) in rheumatoid arthritis patients were evaluated. Baseline data, patient profile, previous and current treatments, cause of discontinuation and information on reintroduction of... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Rheumatoid arthritis; Biological drugs/treatment interruption; Tofacitinib; Adverse events. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000400617 |
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| Registros recuperados: 11 | |
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