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Histopathological changes in albino mouse testis induced by the administration of Tityus n. sp. venom J. Venom. Anim. Toxins
PENNA-VIDEAÚ,S.; CERMEÑO-VIVAS,J.; MORENO-MARVAL,M.; QUIROGA-NOTTI,M..
Scorpion envenoming is a public health concern in northeastern Venezuela. Specimens of the genus Tityus are responsible for most of these. In experimental animals, Tityus venom produces histopathological changes in the skeletal muscle and pancreas, but its toxicity to the reproductive system has not been studied. The aim of this work is to describe the histopathological changes in testis and epididymis of albino mice induced by the administration of Tityus n. sp. venom. Sub-lethal doses of venom (3.75 mg/g mouse) were administered intramuscularly (IM) daily for 4 days. On the fifth day, the animals were sacrificed and the testes and epididymes were quickly removed and processed for light microscopy. The venom induced alterations in spermatogenesis. Sertoli...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Testis; Sertoli cell; Epididymis; Scorpion; Venom; Mouse; Histopathology.
Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-79302000000200003
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