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	Provedor de dados Nature Precedings (1) Autor Feroz Khan (1) Om Prakash (1) R.S. Sangwan (1) Palavra-chave Bioinformatics (1) Tipo do documento Poster (1) Ano 2011 (1) País United Kingdom (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última ANN Based Virtual Classification Model for Discriminating Active and Inactive Withanolide E Analogs against Human Breast Cancer Cell Line MCF-7 Nature Precedings Om Prakash; Feroz Khan; R.S. Sangwan. Withanolides are a group of natural C-28 steroids built on an ergostane skeleton and classified into two major groups according to their structural skeleton: (a) compounds with a beta-oriented side chain and (b) compounds with an alpha-oriented side chain. Withanolide E represents one of the members of the latter group. Classification of active compounds on the basis of pharmacophore against specific cancer cell line poses a serious concern at the primary stage of virtual screening. To overcome this problem we have developed an artificial neural network based virtual screening model for discriminating active and non-active Withanolide-E-like derivatives or analogs against human breast cancer cell line MCF-7. In the present work, a 2D chemical descriptors... Tipo: Poster Palavras-chave: Bioinformatics. Ano: 2011 URL: http://precedings.nature.com/documents/6616/version/1 Registros recuperados: 1 Primeira ... 1 ... Última

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