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| SALVATIERRA,CRISTIANA S.B.; REIS,SÍLVIA R.L.; PESSOA,ANA F.M.; SOUZA,LETÍCIA M.I. DE; STOPPIGLIA,LUIZ F.; VELOSO,ROBERTO V.; REIS,MARISE A.B.; CARNEIRO,EVERARDO M.; BOSCHERO,ANTONIO C.; COLODEL,EDSON M.; ARANTES,VANESSA C.; LATORRACA,MÁRCIA Q.. |
| The phosphatidylinositol 3-kinase and mitogen-activated protein kinase pathways mediate β cell growth, proliferation, survival and death. We investigated whether protein restriction during pregnancy alters islet morphometry or the expression and phosphorylation of several proteins involved in the phosphatidylinositol 3-kinase and mitogen-activated protein kinase pathways. As controls, adult pregnant and non-pregnant rats were fed a normal-protein diet (17%). Pregnant and non-pregnant rats in the experimental groups were fed a low-protein diet (6%) for 15 days. Low protein diet during pregnancy increased serum prolactin level, reduced serum corticosterone concentration and the expression of both protein kinase B/AKT1 (AKT1) and p70 ribosomal protein S6... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: MAP kinase pathway; Pancreatic islets; PI3K pathway; Pregnancy; Protein restriction; Rats. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652015000201007 |
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