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	Provedor de dados Biol. Res. (1) Autor EGUIGUREN,ANA LUISA (1) RIVEROS,ANA (1) SIMON,FELIPE (1) STUTZIN,ANDRES (1) VARELA,DIEGO (1) Palavra-chave Cell Volume (1) Cell death (1) Flufenamic acid (1) Nonselective cation channels (1) Tipo do documento Journal article (1) Ano 2002 (1) País Chile (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Non-selective cation channels and oxidative stress- induced cell swelling Biol. Res. SIMON,FELIPE; VARELA,DIEGO; RIVEROS,ANA; EGUIGUREN,ANA LUISA; STUTZIN,ANDRES. Necrosis is considered as a non-specific form of cell death that induces tissue inflammation and is preceded by cell swelling. This increase in cell volume has been ascribed mainly to defective outward pumping of Na+ caused by metabolic depletion and/or to increased Na+ influx via membrane transporters. A specific mechanism of swelling and necrosis driven by the influx of Na+ through nonselective cation channels has been recently proposed (<A HREF="#2">Barros et al., 2001a</A>). We have characterized further the properties of the nonselective cation channel (NSCC) in HTC cells. The NSCC shows a conductance of ~18 pS, is equally permeable to Na+ and K+, impermeant to Ca2+, requires high intracellular Ca2+ as well as low intracellular ATP for... Tipo: Journal article Palavras-chave: Cell death; Cell Volume; Nonselective cation channels; Flufenamic acid. Ano: 2002 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602002000200013 Registros recuperados: 1 Primeira ... 1 ... Última

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