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| RICHTER,HANS G; TORRES-FARFÁN,CLAUDIA; ROJAS-GARCÍA,PEDRO P; CAMPINO,CARMEN; TORREALBA,FERNANDO; SERÓN-FERRÉ,MARÍA. |
| The circadian time-keeping system ensures predictive adaptation of individuals to the reproducible 24-h day/night alternations of our planet by generating the 24-h (circadian) rhythms found in hormone release and cardiovascular, biophysical and behavioral functions, and others. In mammals, the master clock resides in the suprachiasmatic nucleus (SCN) of the hypothalamus. The molecular events determining the functional oscillation of the SCN neurons with a period of 24-h involve recurrent expression of several clock proteins that interact in complex transcription/translation feedback loops. In mammals, a glutamatergic monosynaptic pathway originating from the retina regulates the clock gene expression pattern in the SCN neurons, synchronizing them to the... |
| Tipo: Journal article |
Palavras-chave: Biological rhythms; Circadian timing system; Clock genes; Melatonin. |
| Ano: 2004 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602004000100003 |
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| RECABARREN,SERGIO E; SIR-PETERMANN,TERESA; LOBOS,ALEJANDRO; CODNER,ETHEL; ROJAS-GARCÍA,PEDRO P; REYES,VÍCTOR. |
| Similar to women with Polycystic Ovary Syndrome (PCOS), female sheep treated prenatally with testosterone (T-females) are hypergonadotropic, exhibit neuroendocrine defects, multifollicular ovarian morphology, hyperinsulinemia and cycle defects. Hypergonadotropism and multifollicular morphology may in part be due to developmentally regulated increase in pituitary responsiveness to GnRH and may culminate in increased ovarian estradiol production. In this study, we utilized a GnRH agonist, leuprolide, to determine the developmental impact of prenatal testosterone exposure on pituitary-gonadal function and to establish if prenatal exposure produces changes in the reproductive axis similar to those described for women with PCOS. Eight control and eight... |
| Tipo: Journal article |
Palavras-chave: Androgenized females; Fetal programming; PCOS; Leuprolide; Female sheep. |
| Ano: 2005 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602005000200013 |
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