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	Provedor de dados Anais da ABC (AABC) (2) Autor RUMJANEK,VIVIAN M. (2) CAPELLA,MÁRCIA A. M. (1) COSTA,KELLI M. DA (1) MAIA,RAQUEL C. (1) MARQUES-SANTOS,LUIS F. (1) MELETTI-DE-OLIVEIRA,MICHELE C. (1) PAIVA,LUCIANA S. DE (1) SILVA,JOYLE M.C. DA (1) TRINDADE,GILMA S. (1) VALENTE,RAPHAEL C. (1) WAGNER-SOUZA,KAREN (1) Mais... Palavra-chave ABC transporters (1) B cells (1) Chemosensitisers (1) Immunoregulation (1) Leukaemia (1) Multidrug resistance (1) P-glycoprotein (1) Steroid (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2018 (1) 2001 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Multidrug resistance in tumour cells: characterisation of the multidrug resistant cell line K562-Lucena 1 Anais da ABC (AABC) RUMJANEK,VIVIAN M.; TRINDADE,GILMA S.; WAGNER-SOUZA,KAREN; MELETTI-DE-OLIVEIRA,MICHELE C.; MARQUES-SANTOS,LUIS F.; MAIA,RAQUEL C.; CAPELLA,MÁRCIA A. M.. Multidrug resistance to chemotherapy is a major obstacle in the treatment of cancer patients. The best characterised mechanism responsible for multidrug resistance involves the expression of the MDR-1 gene product, P-glycoprotein. However, the resistance process is multifactorial. Studies of multidrug resistance mechanisms have relied on the analysis of cancer cell lines that have been selected and present cross-reactivity to a broad range of anticancer agents. This work characterises a multidrug resistant cell line, originally selected for resistance to the Vinca alkaloid vincristine and derived from the human erythroleukaemia cell K562. This cell line, named Lucena 1, overexpresses P-glycoprotein and have its resistance reversed by the chemosensitisers... Tipo: Info:eu-repo/semantics/article Palavras-chave: Multidrug resistance; Leukaemia; P-glycoprotein; Chemosensitisers. Ano: 2001 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652001000100007 Glucocorticoid susceptibility and in vivo ABCB1 activity differ in murine B cell subsets Anais da ABC (AABC) COSTA,KELLI M. DA; VALENTE,RAPHAEL C.; SILVA,JOYLE M.C. DA; PAIVA,LUCIANA S. DE; RUMJANEK,VIVIAN M.. Abstract Glucocorticoids are produced and released by the adrenal gland and become elevated in response to stress. Although glucocorticoids are well known for their immunosuppressive effects, less is known about their effects on B cells. ABCB1 is an efflux pump expressed in both cancer and normal cells, modulating the gradient of various metabolites, including hydrocortisone. Our goal was to evaluate the effect of this glucocorticoid on murine B cell differentiation and whether sensitivity to hydrocortisone could be related to ABCB1 activity in vivo. C57BL/6 mice received one or three consecutive i.p. injections of hydrocortisone (70, 140 and 200 mg/kg/day). ABCB1 activity was evaluated via the rhodamine-123 transport and inhibited by cyclosporin A in... Tipo: Info:eu-repo/semantics/article Palavras-chave: ABC transporters; B cells; Immunoregulation; Steroid. Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000603081 Registros recuperados: 2 Primeira ... 1 ... Última

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