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The concentration of homocysteine-derived disulfides in human coronary artery Nature Precedings
Mauro Iuliano; Gaetano De Tommaso; Liberato Ciavatta; Raffaele Ragone.
*Background* 
Based on previous findings, we have estimated that, in injured coronary artery tissue, the low molecular weight disulfides homocystine and cysteine-homocysteine, otherwise identified as oxidized homocysteine equivalents (OHcyE), may achieve a total concentration that is higher than the aqueous solubility of homocystine at room temperature. In order to verify whether or not OHcyE could reach their saturation limit in the vascular tissue, we have measured the solubility of homocystine in physiological-like condition.

*Materials and methods* 
The solubility of homocystine has been measured in aqueous sodium chloride solutions at 37 °C by differential pulse polarography...
Tipo: Manuscript Palavras-chave: Chemistry; Pharmacology.
Ano: 2007 URL: http://precedings.nature.com/documents/1436/version/1
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Abundance of intrinsic disorder in SV-IV, a multifunctional androgen-dependent protein secreted from rat seminal vesicle Nature Precedings
Silvia Vilasi; Raffaele Ragone.
The potent immunomodulatory, anti-inflammatory and procoagulant properties of the
protein no. 4 secreted from the rat seminal vesicle epithelium (SV-IV) have been
previously found to be modulated by a supramolecular monomer-trimer equilibrium.
More structural details that integrate experimental data into a predictive framework
have recently been reported. Unfortunately, homology modelling and fold-recognition
strategies were not successful in creating a theoretical model of the structural
organization of SV-IV. It was inferred that the global structure of SV-IV is not similar
to any protein of known three-dimensional structure. Reversing...
Tipo: Manuscript Palavras-chave: Bioinformatics.
Ano: 2007 URL: http://precedings.nature.com/documents/1394/version/1
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