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	Provedor de dados Nature Precedings (1) Autor Alwin Goetz (1) Kai Heckel (1) Leoni Schulte-Uentrop (1) Martina Kiefmann (1) Oliver Tritt (1) Paula Keller (1) Rainer Kiefmann (1) Sascha Tank (1) Mais... Palavra-chave Molecular Cell Biology (1) Tipo do documento Manuscript (1) Ano 2011 (1) País United Kingdom (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última A novel alveolar Krebs cycle-triggered CO2 sensing mechanism regulates regional pulmonary ventilation. Nature Precedings Rainer Kiefmann; Paula Keller; Oliver Tritt; Kai Heckel; Sascha Tank; Martina Kiefmann; Leoni Schulte-Uentrop; Alwin Goetz. Pulmonary perfusion disorders provoke atelectasis in order to minimize ventilation/perfusion mismatch. However, the underlying mechanisms remain unknown. Because intraalveolar CO2 concentration ([CO2]iA) declines as a consequence of poor pulmonary perfusion we postulated the existence a novel alveolar CO2-sensing mechanism which adapts the ventilation to perfusion. Real-time fluorescence imaging of rat lungs revealed that low [CO2]iA decreased cytosolic and increased mitochondrial Ca2+ in alveolar epithelial cells (AEC), leading to reduction of surfactant secretion and alveolar ventilation. Mitochondrial inhibition by ruthenium red or rotenone blocked the hypocapnia-induced responses. In cultured Type 2 AEC hypocapnia decreased cytosolic Ca2+ independently... Tipo: Manuscript Palavras-chave: Molecular Cell Biology. Ano: 2011 URL: http://precedings.nature.com/documents/6185/version/1 Registros recuperados: 1 Primeira ... 1 ... Última

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